OBJECTIVE:To investigate the application status of antibiotics in department of respiration before and after special rectification in Guangxi Zhuang Autonomous Region Nanxishan Hospital ( hereinafter referred to as “our hospital”) , and to provide reference for the rational application of antibiotics in clinic .METHODS: The rational application status , data of the consumption sum , defined daily dose system ( DDDs ) of antibiotics in inpatients from department of respiration of certain a hospital during 2010-2014 were retrospectively statistically analyzed .RESULTS:After intervention , the rational application of antibiotics had been improved .Even through the consumption sum and hospitalized cases increased year by year , DDDs and use rate of antibiotics were in a decrease trend .Antibacterial drug DDDs down from 82.6 in 2010 to 40.8 in 2014,and the utilization rate dropped from 93.3%in 2010 to 77.3%in 2014. As for the rational application status , the drug combination rate dropped from 69.9%in 2010 to 54.6%in 2014 were but the specimen bacteria examination rate and effective rate of treatment increased year by year .According to the top 10 antibiotics ranked by DDDs , enzyme inhibitors were preferred in clinical drug use or in combination with macrolide or quinolone .CONCLUSIONS:The special rectification could promote the rational use of antibiotics , specimens were rate rose from 75.0%in 2010 to 95.3% in 2014 and efficient treatment , up from 80.3% in 2010 to 89.7% in 2014 and significantly increase the rationality of antibiotics in department of respiration .The intervention measures adopted by the hospital are effective and feasible , yet the standard management still needs to be strengthened .%目的：调查在抗菌药物专项整治活动前、后广西壮族自治区南溪山医院（以下简称“我院”）呼吸科住院患者抗菌药物的应用情况，为抗菌药物的临床合理用药提供参考。方法：对2010—2014年我院呼吸科住院患者抗菌药物合理使用情况、销售金额、用药频度（ defined daily dose system ，DDDs）等数据进行回顾性统计分析。结果：经过干预，抗菌药物合理使用情况得到改善，销售金额、住院人数虽然逐年升高，但DDDs、抗菌药物使用率呈下降趋势，我院抗菌药物DDDs由2010年82.6下降到2014年40.8，抗菌药物使用率由2010年93.3％下降到2014年77.3％。在合理使用情况中，联合用药率呈下降趋势，由2010年的69.9％下降为2014年的54.6％。标本送检率、治疗有效率逐年升高，标本送检率由2010年75.0％上升至2014年95.3％，治疗有效率由2010年80.3％上升至2014年89.7％。根据DDDs排位居前10位的抗菌药物提示，临床用药倾向于选择加酶抑制剂，或联合使用大环内酯类或氟喹诺酮类。结论：本次专项整治活动有助于促进我院抗菌药物的合理使用，呼吸科抗菌药物使用的合理性有了明显的提高，我院采取的干预措施有效、可行，但有待加大力度，不断规范化管理。
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