目的：探讨3种磺脲类药用于2型糖尿病初始治疗的短期经济学效果。方法：选取2012年8月—2015年8月牡丹江医学院红旗医院收治的2型糖尿病患者180例作为研究对象，以随机数字表法分为格列美脲组、格列喹酮组和格列吡嗪组，每组各60例。格列美脲组患者给予格列美脲4 mg，1日1次；格列喹酮组患者给予格列喹酮15 mg，1日3次；格列吡嗪组患者给予格列吡嗪15 mg，1日1次。12周为1个疗程，治疗过程中检测血糖及糖化血红蛋白（ HbA1 c）。结果：格列美脲组患者的总有效率显著高于格列吡嗪组，格列美脲组患者餐后2 h血糖下降百分率、HbA1 c下降率均显著高于格列喹酮组、格列吡嗪组，差异均有统计学意义（ P＜0．05）；将评价指标设定为餐后2 h血糖下降百分率，格列美脲组、格列喹酮组比格列吡嗪组分别增加了8．44、17．54元；将评价指标设定为HbA1 c下降率，格列美脲组、格列喹酮组比格列吡嗪组分别增加了36．49、53．96元；餐后2 h血糖下降百分率、HbA1 c下降率均不敏感于药品价格；3组患者的不良反应发生率之间的差异均无统计学意义（ P＞0．05）。结论：格列美脲较格列喹酮与格列吡嗪初治2型糖尿病短期经济学效果好。%OBJECTIVE:To probe into the short-term economic effects of 3 kinds of sulfonylurea drugs in the initial treatment of type II diabetes .METHODS: 180 patients with type II diabetes admitted into Hongqi Hospital of Mudanjiang Medical University from Aug .2012 to Aug .2015 were selected to be divided into glimepiride group , gliquidone group and glipizide group via the random number table , with 60 cases in each .Patients in glimepiride group were treated with glimepiride 4 mg, once a day;the gliquidone group were given gliquidone 15 mg, 3 times a day;and the glipizide group received glenn pyrazine 15 mg, once a day; 12 weeks for a treatment course .And the blood glucose , HbA1 c were determined during the treatment process .RESULTS:The total effective rate of glimepiride group was was significantly higher than that of glipizide group;the decent percentage of blood glucose after 2 h and HbA1 c of glimepiride group were significantly higher than those of gliquidone group and glipizide group , with statistically significant difference ( P 0.05).CONCLUSIONS:The short-term economics effects of glimepiride is better than gliquidone and glipizide in the initial treatment of type 2 diabetes.
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