OBJECTIVE:To investigate the compliance and influencing factors of methadone maintenance treatment in drug addict .METHODS: 98 drug addicts accepting methadone maintenance treatment in Methadone outpatient department of Dongguan from Feb .2013 to Dec.2014 were selected;among which 49 cases did not participate in the administration for a total of more than 15 days within 3 months were set as depigmentation group;and another 49 cases participate in the administration for 6 months were set as maintenance group .The baseline data ( gender, age, educational level, social support, and marriage, etc.), the heroin craving scores and urine morphine positive rate of two group were compared and analyzed after treatment of 8 months.RESULTS: After treatment of 8 months, the average heroin craving scores and urine morphine positive rate of depigmentation group were respectively ( 23.97 ± 2.18 ) scores and ( 89.37 ±0.36 )%, significantly higher than those of maintenance group [ ( 20.06 ±1.87 ) scores and ( 76.23 ±1.02 )%] , with statistically significant difference ( P <0.05 ) .There were statistically significant differences between two groups in gender , age , educational level , social support , and marriage ( P <0.05 ) . CONCLUSIONS:The compliance of methadone maintenance treatment is affected by many factors , and the clinical application of targeted measures should be taken to improve the compliance of patients .%目的：探讨吸毒患者对美沙酮维持治疗的依从性及其影响因素。方法：选取2013年2月—2014年12月东莞市美沙酮门诊接受美沙酮维持治疗的吸毒患者98例，其中49例为3个月内累计超过15 d不参加服药者，为脱失组；49例为超过6个月一直接受美沙酮维持治疗者，为维持组。对比分析2组吸毒患者的基线资料（性别、年龄、文化程度、社会支持情况及婚姻状况等），以及治疗8个月后的海洛因渴求评分、尿吗啡阳性率。结果：治疗8个月后，脱失组吸毒患者的平均海洛因渴求评分为（23．97±2．18）分、平均尿吗啡阳性率为（89．37±0．36）％，均明显高于维持组的（20．06±1．87）分、（76．23±1．02）％，差异均有统计学意义（P＜0．05）；2组吸毒患者的性别、年龄、文化程度、社会支持情况、婚姻状况等比较，差异均有统计学意义（P＜0．05）。结论：吸毒患者对美沙酮维持治疗的依从性受多因素影响，临床应采取针对性的措施，以提高患者依从性。
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