OBJECTIVE:To probe into the characteristics of occurrence of adverse drug reactions( ADR) induced by antibiotics in Yong’an Municipal Hospital( hereinafter referred to as“our hospital”) , so as to provide reference for the rational drug use in clinic.METHODS: 256 cases of ADR by our hospital from Jan.2008 to Jun.2016 were collected and reported;statistical analysis was conducted on patients’gender, allergic history, route of administration, drugs and clinical manifestations of ADR, ADR-involved organs and( or) systems, etc..RESULTS:ADR induced by antibiotics occurred in all ages, among which individuals aged 15-44 years old had the highest incidence of ADR (41.89%, 111 cases);the main route of administration was intravenous injections(248 cases);the number of cases that induced by cephalosporins antibiotics took the lead (115 cases);levofloxacin induced the most cases of ADR(61 cases);ADR induced by antibiotics can involve multiple systems and( or) organs, the most common was the skin and its accessories damage.CONCLUSIONS: It is necessary to pay attention to and strengthen the monitoring of ADR induced by antibiotics and the rational drug use, so as to guarantee the medication safety in patients.%目的：探讨永安市立医院（以下简称“我院”）抗菌药物致不良反应发生的特点，为临床合理用药提供参考。方法：针对我院2008年1月—2016年6月收集并上报的265例抗菌药物致不良反应报告，分别从患者性别与年龄、过敏史、给药途径、涉及药品及不良反应的临床表现、累及器官和（或）系统等方面进行统计分析。结果：抗菌药物致不良反应可发生于各个年龄段患者，其中15～＜45岁患者使用抗菌药物后的不良反应发生率最高，为41．89％（111例）；静脉滴注是抗菌药物引发不良反应的主要给药途径（248例）；头孢菌素类抗菌药物发生的不良反应病例数最多（115例）；引发不良反应病例数最多的具体药品为左氧氟沙星（61例）；抗菌药物致不良反应可累及多个器官和（或）系统，最多见的是皮肤及其附件损害。结论：应重视和加强抗菌药物致不良反应监测，合理用药，保障患者用药安全。
展开▼
