OBJECTIVE:To probe into the efficacy and safety of Escitalopram oxalate tablets combined with Quetiapine fumarate tablets in treatment of depression.METHODS:100 patients with depression admitted into Jinzhou Kangning Hospital from Oct.2013 to Oct.2015 were selected to be divided into observation group and control group via the random number table, with 50 cases in each.The control group were treated with Escitalopram oxalate tablets, while the observation group received Escitalopram oxalate tablets combined with Quetiapine fumarate tablets.The efficacy and adverse drug reactions of two groups were observed.RESULTS: The total effective rate of observation group was 84.0%( 42/50 ) , significantly higher than that of control group [ 54.0%( 27/50 ) ] , with statistically significant difference( P0.05).The incidence of adverse drug reactions in observation group and control group were respectively 12.0%( 6/50 ) and 14.0%( 7/50 ) , without any statistically significant difference( P<0.05) .CONCLUSIONS:The effects of Escitalopram oxalate tablets combined with Quetiapine fumarate tablets in treatment of depression is effective, with few adverse drug reactions and high safety.%目的：探讨草酸艾司西酞普兰片联合喹硫平片治疗抑郁症的疗效及安全性。方法：选取2013年10月—2015年10月锦州市康宁医院收治的抑郁症患者100例作为研究对象，以随机数字表法分为观察组和对照组各50例。对照组患者给予草酸艾司西酞普兰片治疗，观察组患者给予草酸艾司西酞普兰片联合喹硫平片治疗。观察2组患者的疗效及不良反应。结果：观察组患者的总有效率为84．0％（42／50），显著高于对照组的54．0％（27／50），差异有统计学意义（P＜0．05）；2组患者治疗2、4、8周后的汉密尔顿抑郁量表（ hamilton depression scale，HAMD）评分均明显低于治疗前，差异有统计学意义（ P＜0．05）；治疗2、4、8周后，2组患者HAMD评分的差异无统计学意义（P＞0．05）；观察组、对照组患者的不良反应发生率分别为12．0％（6／50）、14．0％（7／50），差异无统计学意义（ P＞0．05）。结论：草酸艾司西酞普兰片联合喹硫平片治疗抑郁症，效果确切，不良反应较少，安全性较高。
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