OBJECTIVE:To compare the major bioactive components between Radix scutellariae with xylem rotten and Strip type radix scutellariae , so as to provide reference of drug purchaseing for pharmacy and clinical application in clinic . METHODS:HPLC method was adopted, the chromatographic column was Agilent ZORBAX-Eclipse XDB C18 (25 cm × 4.6 mm,5μm), with mobile phase of methanol-water-phosphoric acid(V∶V∶V=47∶53∶0.2)and flow rate of 1 ml/min, and detection wavelength at 280 nm.Correlation between each set of data was analyzed by SAS 8.2 software.RESULTS:The average content of baicalin in Radix scutellariae with xylem rotten was 12.80%, the average content of baicalein was 2.01%;and the average content of baicalin in Strip type radix scutellariae was 13.14%, the average content of baicalein was 1.35%.According to the analysis , the differences were statistically significant among the average content of baicalin in Radix scutellariae with xylem rotten and Strip type radix scutellariae , the average content of baicalein ( P <0.05 ). CONCLUSIONS:The content of baicalein is relatively high in Radix scutellariae with xylem rotten , while baicalin is relatively high in Strip type radix scutellariae .So it’ s impossible to tell which is better than the other .The conclusion of this study can provide reference of drug purchaseing for pharmacy and clinical application in clinic .%目的：比较黄芩饮片枯芩、条芩部分主要活性成分的含量，为医院药房采购及临床用药提供参考。方法：采用高效液相色谱法，色谱柱为Agilent ZORBAX－Eclipse XDB C18色谱柱（25 cm ×4．6 mm，5μm）；流动相为甲醇－水－磷酸（V∶V∶V＝47∶53∶0．2）；流速1 ml／min；检测波长280 nm。使用SAS 8．2软件分析各组数据之间的相关性。结果：枯芩中黄芩苷平均含量为12．80％，黄芩素平均含量为2．01％；条芩中黄芩苷平均含量为13．14％，黄芩素平均含量为1．35％。分析结果显示，枯芹、条芹中黄芩苷、黄芩素平均含量的差异均有统计学意义（ P＜0．05）。结论：枯芩中黄芩素含量较高，条芩中黄芩苷含量较高，因此不能断论其中一种优于另一种，本研究结论可为药房采购及临床用药提供参考。
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