目的：探讨甘露醇与尼莫地平联合治疗高血压脑出血的临床疗效及对血流动力学的影响。方法：选择2011年1月—2015年12月萍乡市第二人民医院收治的100例高血压脑出血患者，以随机数字表法分为对照组和观察组，每组各50例。对照组患者采用甘露醇静脉滴注治疗，观察组患者在对照组基础上加用尼莫地平治疗。比较2组患者临床治疗效果及治疗前后血流动力学参数变化情况。结果：观察组患者临床治疗总有效率为88％（44／50），显著高于对照组的70％（35／50），差异有统计学意义（P＜0．05）。治疗后，2组患者血肿体积和美国国立卫生研究院卒中量表评分均较治疗前明显降低，且观察组患者降低程度明显高于对照组，差异均有统计学意义（P＜0．05）；2组患者血流量、血流速度、外周阻力和临界压力等血流动力学指标均较治疗前明显改善，且观察组患者改善程度明显高于对照组，差异均有统计学意义（ P＜0．05）。结论：甘露醇与尼莫地平联合治疗高血压脑出血，疗效满意，血流动力学指标改善良好。%OBJECTIVE:To study the clinical efficacy of mannitol combined with nimodipine in treatment of hypertensive cerebral hemorrhage and effects on hemodynamics .METHODS: 100 patients with hypertensive cerebral hemorrhage admitted into the Second People’s Hospital of Pingxiang from Jan.2011 to Dec.2015 were selected to be divided into observation group and control group via the random number table , with 50 cases in each.The control group were treated with intravenous mannitol , while the observation group additionally received nimodipine based on the control group .The clinical effects and changes of hemodynamic indicators were compared between two groups before and after treatment . RESULTS:The total effective rate of observation group was 88%(44/50), significantly higher than that of control group [70%(35/50)], with statistically significant difference(P<0.05).After treatment of one month, the hematoma volume and MIHSS score of two groups decreased compared with before treatment , and the observation group decreased more significantly than the control group, with statistically significant difference(P<0.05).The hemodynamic indicators as blood flow volume, blood flow velocity, peripheral resistance and critical pressure in both groups had been improved , and the improvement in observation group were more significant than that of control group , with statistically significant difference (P<0.05).CONCLUSIONS: The efficacy of mannitol ombined with nimodipine in treatment of hypertensive cerebral hemorrhage is remarkable , which helps to improve the hemodynamic indicators .
展开▼
