OBJECTIVE:To study the feasibility of treatment of senile hyperlipidemia with different doses of simvastatin.METHODS:From May 2012 to May 2014, a total of 72 elderly patients with hyperlipidemia treated in Bethune International Peace Hospital of the Chinese People's Liberation Army were randomly divided into 2 groups. The control group was treated with small dose simvastatin butyl (20 mg/d) and the observation group with a high dose simvastatin (40 mg/d ) .The clinical efficacy and drug safety of the two groups were compared, and blood lipids improvement in two groups was evaluated.RESULTS: The overall response rate of the observation group was significantly higher than in the control group (94.4% vs.80.6%; P0.05 ) , but after treatment, all indexes improved with better improvement showing in the observation group than in the control group ( P<0.05) .The treatment cost in the observation group was higher than in the control group (P<0.05).CONCLUSIONS:Treatment of elderly patients with hyperlipidemia using high dose simvastatin resulted in better efficacy and safety and better improvement in blood lipids in spite of its high treatment cost, which thus is worth of clinical popularization.%目的：探讨不同剂量辛伐他汀治疗老年高脂血症的可行性。方法：选取2012年5月—2014年5月解放军白求恩国际和平医院收治的老年高脂血症患者共72例，以随机数字表法将其等分成2组，对照组应用小剂量辛伐他汀（20 mg／d）治疗，观察组给予高剂量辛伐他汀（40 mg／d）用药，研究2组的临床治疗效果和用药安全性，同时评估其施治前后的血脂改善情况。结果：观察组治疗后的临床总有效率为94.4％显著高于对照组的80.6％（ P＜0.05）。治疗前，2组患者的总胆固醇、三酰甘油、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇等指标值相似（P＞0.05），经治疗后均改善，且观察组较对照组改善更显著（P＜0.05）。在治疗成本上，观察组较对照组高，差异有统计学意义（ P＜0.05）。结论：对老年高脂血症患者实施高剂量辛伐他汀进行治疗，虽然治疗成本较高，但疗效更显著，对血脂水平改善效果更理想，且安全性佳，值得在临床普及推广。
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