目的：了解东莞市厚街医院（以下简称“我院”）药品不良反应（ adverse frug reaction，ADR）发生的原因和特点，促进临床合理用药。方法：对2011—2014年我院呈报的388例ADR报告进行回顾性分析。结果：388例ADR报告中，男性患者227例，女性患者161例，男性多于女性；20～＜40岁患者居多（194例，占50．00％）；引发ADR的主要给药途径为静脉滴注（287例次，占合计455例次的63．08％），药物剂型以注射剂和粉针剂为主；抗感染药引起的ADR病例数最多（241例次，占合计455例次的52．97％），其次为中成药；ADR最常见的临床表现为皮肤及其附件损害（205例次，占合计455例次的45．05％）。结论：抗感染药、中成药是ADR监测的重点药物，应加强特殊人群、静脉给药方式和重点药物的ADR监测，提高合理用药水平，减少药源性疾病的发生。%OBJECTIVE:To investigate the causes and characteristics of the adverse drug reactions ( ADRs ) in Dongguan Houjie Hospital ( hereinafter referred to as“our hospital”) so as to promote clinical rational use of drugs. METHODS:A retrospective analysis of 388 ADR cases in our hospital from 2011 to 2014 was carried out.RESULTS:Of the total 388 cases, males showed higher proportion than did females(227 males versus 161 females);patients aged from 20 years to less than 40 years showed the highest proportion(194 cases, 50.00%);ADR was caused mainly by intravenous injections(287 cases, accounted for 63.08%); in terms of dosage forms, injection and power injection showed the highest proportion;the ADRs were mostly induced by anti-infective drugs(241/455,52.97%) and then by the Chinese patent medicines;the ADRs manifested mostly as damage of skin and its appendages(205/455 cases,45. 05%) .CONCLUSIONS: Anti-infective drugs and Chinese patent medicines should be the focus of the ADR monitoring.It is important to strengthen ADR monitoring among special populations, intravenously administered and key drugs so as to improve the level of rational use of drugs and reduce the incidence of drug-induced disease.
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