目的:比较白细胞介素11(IL-11)含漱液与维生素B12含漱液治疗放射性黏膜炎的疗效. 方法:将125例行头颈癌患者在进行根治性放疗期间按随机数字表法分为观察组(63例)和对照组(62例),观察组患者采用IL-11含漱液治疗,对照组患者采用维生素B12含漱液治疗,比较2组的治疗效果. 结果:与对照组比较,观察组患者的口腔黏膜炎较轻(P=0. 072),有15例(15/62, 24. 19%)黏膜炎在放疗期间痊愈,对照组无黏膜炎痊愈患者( P=0. 049 );与对照组比较,观察组患者黏膜疼痛较轻( P=0. 058 ) ,且服用阿片类药物止痛的频率也较低( P =0. 042 );对照组10 例患者在放疗期间因黏膜炎住院,观察组无此情况出现( P =0. 035);对照组13例患者(13/62,20. 97%)需中断放疗,观察组无此情况出现(P=0. 042). 结论:IL-11含漱液预防放射性黏膜炎和治疗黏膜炎疼痛方面比维生素B12含漱液更有效,使用L-11含漱液可减少因黏膜炎而中断放疗的次数.%OBJECTIVE:To compare the efficacy of interleukin 11 (IL-11) mouthwash and vitamin B12 mouthwash in treatment of radiation mucositis. METHODS:125 cases of patients with head and neck cancer radical resection treated with postoperative radiotherapy were randomly divided into observation group (63 cases) and control group (62 cases) , the observation group received IL-11 mouthwash therapy and the control group received vitamin B12 mouthwash therapy, the clinic efficacy in two groups were compared. RESULTS: The oral mucositis of observation group was mild ( P =0. 072),15 cases (15/62,24. 19%) healed during radiotherapy. As for the control group, there was no recovery (P=0. 049). The mucosal pain of patients in observation group was low (P=0. 058), and the frequency of taking opioid analgesics was also low (P=0. 042). 3 patients in control group hospitalized due to mucositis, during radiotherapy and the observation group did not have this situation(P=0. 035). There were 13 cases(13/62,20. 97%)with interruption of radiotherapy in control group, while no case in observation group (P=0. 042). CONCLUSIONS:IL-11 mouthwash gargle has a more effective efficacy than vitamin B12 mouthwash gargle in radiation mucositis prevention and treatment of mucositis pain, which can reduce the number of interruption of radiotherapy due to mucositis.
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