目的:探讨质子泵抑制剂对幽门螺杆菌( helicobacter pylor,Hp)阳性反流性食管炎患者的临床疗效. 方法:选取2014年1月-2014年12月无锡市惠山区人民医院收治的100例Hp阳性反流性食管炎患者,根据住院编号分为观察组和对照组各50例,2组患者均给予抗Hp治疗. 对照组患者在此基础上给予多潘立酮治疗,观察组患者则给予奥美拉唑治疗,对比2 组患者的疗效及不良反应. 结果:观察组患者的总有效率为94. 00%( 47/50 ) ,明显高于对照组的82. 00%( 41/50 ) ,差异有统计学意义(P<0. 05);观察组患者不良反应发生率为2. 00%(1/50),明显低于对照组的10. 00%(5/50),差异有统计学意义(P<0. 05). 结论:Hp阳性反流性食管炎患者采用抑酸剂配合治疗的效果要显著优于促胃肠动力药,不良反应发生率较低,值得临床推广.%OBJECTIVE:To investigate the clinical efficacy of proton pump inhibitors on patients with helicobacter pylor ( Hp) positive reflux esophagitis. METHODS: 100 cases of Hp positive reflux esophagitis from Jan. 2014 to Dec. 2014 were selected as the objects, according to the hospitalized number, were divided into observation group and control group, with 50 cases in each group. Two groups were treated with anti Hp therapy, the control group was additionally given domperidone treatment, the observation group was given omeprazole treatment. The efficacy and adverse drug reaction were compared between two groups. RESULTS: the total efficiency of observation group was 94. 00%(47/50), and the control group was 82. 00%(41/50), the observation group was significantly better than the control group, the difference was statistically significant ( P<0. 05 ) . The adverse reaction of observation group was 2. 00%( 1/50 ) , which was significantly lower than that of the control group 10. 00% ( 5/50 ) , with statistically significant difference ( P<0. 05 ) . CONCLUSIONS:The efficacy of treating with anti acid agents on patients with Hp positive reflux esophagitis is better than that with prokinetic drugs. The incidence of adverse reaction is low, and the method is worthy of clinical popularization and application.
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