目的：探讨口服低剂量罗红霉素联合鼻腔冲洗预防鼻咽癌放疗术后鼻窦炎的临床疗效。方法：选取2011年1月—2014年3月3家医院经病理确诊的鼻咽癌患者128例，以随机数字表法分为观察组62例与对照组66例。对照组患者给予常规放疗；观察组患者在放疗的同时口服低剂量罗红霉素，并使用0.9％氯化钠注射液进行鼻腔冲洗。比较2组患者鼻窦炎发生情况与治疗前后头痛、流涕、鼻塞及嗅觉减退评分。结果：观察组患者鼻窦炎发生率为9.68％（6／62），显著低于对照组的22.73％（15／66），差异有统计学意义（P＜0.05）。治疗前，2组患者头痛、鼻塞、嗅觉减退和流涕评分的差异均无统计学意义（P＞0.05）；治疗后，观察组患者头痛、鼻塞、嗅觉减退和流涕评分均显著优于对照组，差异均有统计学意义（ P＜0.05）。结论：鼻咽癌患者在放疗中配合口服罗红霉素，并使用0.9％氯化钠注射液进行鼻腔冲洗，能有效降低鼻咽癌患者放疗后鼻窦炎的发生率，可为患者放疗术后的生活创造良好的条件，改善其生活质量。%OBJECTIVE:To investigate the clinic efficacy of low dose roxithromycin combined with nasal douche in prevention of nasosinusitis after nasopharyngeal carcinoma ( NPC) radiotherapy .METHODS:128 cases with NPC that confirmed by pathological diagnosis from Jan .2011 to Mar.2014 in three hospitals were divided into observation group with 62 cases and control group with 66 cases via the random number table .The control group received conventional radiotherapy;based on the control group , the treatment group was additionally given low dose roxithromycin orally combined with nasal douche of 0.9% sodium chloride injection .The incidence of nasosinusitis , headache , runny nose , rhinobyon and hyposmia scores before and after treatment were compared between two groups .RESULTS: The incidence of nasosinusitis in observation group was 9.68%( 6/62 ) , which was significantly lower than that in control group [22.73%(15/66)], with statistically significant difference (P 0.05 ) .After treatment , headache , rhinobyon , hyposmia and runny nose scores in observation group were significant higher than that in control group , with statistically significant difference ( P <0.05 ) .CONCLUSIONS: To treat the patients with NPC with radiotherapy , oral roxithromycin and nasal douche of 0.9% sodium chloride injection , can effectively reduce the incidence of nasosinusitis after radiotherapy , create better life conditions and improve the quality of life for the patients after radiotherapy .
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