OBJECTIVE:To investigate the clinical efficacy of tirofiban combined with low-dose heparin in treatment of progressive stroke with intracranial and extracranial arterial stenosis .METHODS:128 cases of patients with progressive stroke with intracranial and extracranial arterial stenosis were divided into observation group and control group according to random number table , with 64 cases in each group .The control group only received heparin treatment, the observation were treated with low-dose heparin combined with tirofiban .RESULTS: After treatment, NIHSS scores of 1 d、2 d、3 d、1 week in observation group were significantly lower than those in control group , with statistically significant difference ( P<0.05 ) .The rate of recovery , rate of mild to moderate stenosis in extracranial intracranial vascular were significantly higher than that of the control group , with statistically significant difference ( P<0.05 ) .The improvement time of artery stenosis in observation group was ( 3.6 ±1.2 ) d, and in control group was (5.8 ±2.1 ) d, there was statistically significant difference between two groups ( P <0.05 ) .The rate of novo-infarction、stroke was 3.13%in observation group, which was significantly lower than that in control group (9.38%), with statistically significant difference ( P<0.05 ) .CONCLUSIONS: The application of tirofiban combined with low-dose heparion in treatment of progressive stroke and intracranial with extracranial arterial stenosis can effectively reduce the neurological deficit , improve prognosis .It is worthy of popularization and application .%目的：探讨替罗非班联合小剂量肝素治疗进展性脑卒中合并颅内、外血管狭窄的临床疗效。方法：将128例进展性脑卒中合并颅内、外血管狭窄患者按随机数字表法分为观察组和对照组各64例，对照组患者单用肝素进行治疗，观察组患者联合应用小剂量肝素和替罗非班。结果：治疗后，观察组患者1d、2d、3d、1周的神经功能缺损评分均显著低于对照组，差异有统计学意义（P＜0.05）；观察组患者的预后改善率，血管轻、中度狭窄率均显著高于对照组，差异有统计学意义（P＜0.05）；观察组患者的动脉狭窄改善时间为（3.62±1.23） d，明显短于对照组的（5.85±2.11） d，差异有统计学意义（P＜0.05）；观察组患者再梗及卒中发生率为3.13％，明显低于对照组的9.38％，差异有统计学意义（P＜0.05）。结论：对进展性脑卒中合并颅内、外血管狭窄患者联合应用替罗非班和小剂量肝素进行治疗，可有效改善神经功能缺损情况，改善预后，值得推广。
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