目的：了解云南省第一人民医院（以下简称“我院”）门诊口服抗高血压药的使用情况及趋势，为临床合理用药提供参考。方法：收集我院门诊2014年43680张处方，采用Excel软件，对患者资料和处方中口服抗高血压药的品种、用量、销售金额、用药频度、限定日费用等进行统计分析。结果：高血压病患病率随年龄增长而增加；43680张处方中，应用抗高血压药处方11820张，占27.06％；抗高血压药销售金额为215.04万元，占抽查处方总金额（1480.2万元）的14.53％。销售金额和使用频次排序居前3位的抗高血压药种类为钙通道阻滞剂、血管紧张素Ⅱ受体阻断剂、β受体阻断剂；抗高血压药联合应用率为39.80％，其中以二联用药为主。厄贝沙坦片与苯磺酸氨氯地平片的销售金额、用药频度排序均居第1、2位，其B／A均为1，说明其销售金额与用药频度的同步性好。结论：我院门诊口服抗高血压药的使用基本合理，符合抗高血压药的用药原则。%OBJECTIVE:To investigate the application situation and tendency of oral anti-hypertensive drugs of outpatients in the First People's Hospital of Yunnan Province ( hereinafter referred to as “our hospital”) , and to provide reference for the rational drug use in clinic .METHODS:43680 outpatient prescriptions in our hospital in 2014 were collected, Excel software was adopted to statistically analyze the general information of patients , the varieties, quantity, consumption sum, daily defined doses(DDDs) and defined daily cost(DDC)of oral anti-hypertensive drugs. RESULTS:Incidence of hy-pertension increased with the increase of age .Of the 43 680 outpatient prescriptions , 11 820 prescriptions used anti-hypertensive drugs , accounting for 27.06%;the consumption sum of anti-hypertensive drugs were 2.150 4 million yuan, accounting for 14.53%of the total amount of sampled prescriptions (1 4.802 million yuan).According to the ranking of consumption sum and the use frequency , the top 3 places were in turn calcium antagonist(CCB), angiotensinⅡreceptor antagonist(ARB) andβreceptor blocking agents(β-RB).The combination use rate of anti-hypertensive drugs was 39.8%, mainly with double combination of drugs .The consumption sum and DDDs of Irbesartan tablets and Amlodiping besylate tablets respectively dominated the first and second place ,with order ratio of 1 for both drugs , which indicated the good synchronization between consumption sum and DDDs . CONCLUSIONS:The application of anti-hypertensives drugs was basically rational in outpatient department of our hospital , which in line with the current oral anti-hypertensive medication principle .
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