OBJECTIVE:To investigate the incidence of adverse drug reaction ( ADR) and probe into the influential factors of ADR, so as to provide reference for rational drug use in clinic .METHODS: 673 cases of ADR reports collected in inpatient and outpatient department of Center Hospital of Shandong Sishui County Shengshui Town during 2010-2013 were retrospectively reviewed and analyzed .RESULTS:Of the 673 ADR patients, patients that >60 years old took the highest proportion , accounting for 37.59%(253 cases);the number of ADR cases induced by intravenous drip took the lead of route of administration , totally 549 cases(81.58%);and ADR brought on by antibiotics also at the head, totally 368 cases (54.68%);ADR mainly involved skin and its accessories , totally 416 cases (36.20%). CONCLUSIONS:The incidence of ADR are intimately connected with the route of administration and age of patients , and ADR that induced by intravenous drip should be paid close attention .%目的：了解药品不良反应（ adverse drug reaction ，ADR）发生情况，探讨影响ADR发生的因素，为临床合理用药提供参考。方法：2010—2013年山东省泗水县圣水峪中心卫生院门诊与住院临床科室上报的673例ADR进行回顾性统计分析。结果：发生ADR的673例患者中，＞60岁患者所占比例最高，为37.59％（253例）；静脉滴注给药引起的 ADR例数最多，为549例（占81.58％）；抗感染药引起的ADR例数最多，为368例（占54.68％）；ADR主要累及皮肤及其附件，为416例（占36.20％）。结论：ADR的发生与给药途径、患者的年龄关系密切，应重点关注静脉滴注给药引发的ADR。
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