目的：了解江苏省原子医学研究所附属江苏省江原医院（以下简称“我院”）门诊普拉克索使用情况，为临床合理用药提供参考。方法：抽取我院2011—2013年诊断为帕金森病（ PD）的所有门诊处方共计7688张，从中随机抽取1200张，收集患者的性别、年龄、用药情况等信息资料，对不同年龄段患者用药情况进行统计分析。结果：普拉克索在70岁以下患者中用量较大，随着年龄的增长，使用普拉克索的处方数比例逐渐下降，＜50岁、50～＜60岁、60～＜65岁、65～＜70岁年龄段使用普拉克索比例分别为80.70％、65.28％、64.81％、55.03％；而联合使用复方左旋多巴的处方数比例逐渐增加。普拉克索销售金额和用药频度（DDDs）增长很快，限定日费用（ DDC）较高。结论：我院普拉克索的使用比较合理，符合PD治疗指南，但由于普拉克索价格较贵，患者经济负担较重，因此在药物选择上需要根据患者病情的特点、年龄、职业、经济状况等因素综合考虑，从中选择比较合适药物，以便于提高患者的生活质量。%OBJECTIVE:To investigate the utilization of pramipexole in outpatients from Jiangyuan Hospital Affiliated to Jiangsu Institute of Atomic Medicine (“hereinafter referred to as our hospital”) so as to provide reference for clinical rational use of drug.METHODS:7 688 outpatient prescriptions of patients with Parkinson's disease ( PD) were randomly collected, from which 1 200 were randomly selected for statistical analysis regarding patients’ gender, age, and the drug use in different age group.RESULTS: Pramipexole was used more frequently in <70 years patients.The increase of patients ’ age was associated with the decrease of the proportion of the prescriptions of pramipexole.The proportions of the patients aged <50、50~<60、60~<65、65~<70 years who used pramipexole stood at 80.70%, 65.28%, 64.81% and 55.03% respectively.The proportion of the prescriptions of pramipexole plus Benserazide gradually increased.Pramipexole witnessed rapid increase in both consumption sum and DDDs and its DDC was high.CONCLUSIONS: The utilization of pramipexole in our hospital is was rational and conforms to the guideline of PD treatment.However, with high price, Pramipexole incurs heavy economic burden for patients, therefore, in choosing drugs, the factors such as the characteristics of patients’ state of disease, age, occupation and economic status should be considered so as to choose the suitable drug and improve patients’ quality of life.
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