OBJECTIVE: To evalute the efficay and safety of mifepristone plus misoprostol for terminating early pregnancy. METHODS: A total of 174 women undergoing termination of early pregnancy in Henan Yuzhou Family Planning Propaganda & Guidance Station( hereinafter referred to as “our station”) from June 2013 to July 2014 were randomly assigned to receive either conventional⁃dose of mifepristone tablets plus misoprostol ( control group ) or small dose of mifepristone capsules plus misoprostol( observation group) , of 87 each. RESULTS: The degree of abdominal pain in the observation group was significantly milder, and the data regarding vaginal bleeding, uterine contraction time and abortion time and the efficacy of abortion etc were significantly better than in the control group, and the differences between the two groups were statistically significant ( P <0�05 ); the adverse reactions in the observation group was significantly milder than in the control group(P<0�05). CONCLUSIONS:Compared withconventional⁃dose of mifepristone tablets plus misoprostol, the small dose of mifepristone tablets plus misoprostol showed better efficacy and safety in terminating early pregnancy which thus is worthy of recommendation in clinical use.%目的：探讨米非司酮联合米索前列醇终止早期妊娠的效果与安全性。方法：收集2013年6月—2014年7月禹州市计划生育技术宣传指导站（以下简称“我站”）收治的拟终止早期妊娠的妇女174例，按照数字随机原则分为观察组与对照组各87例，对照组采用米非司酮片常规剂量联合米索前列醇进行治疗，观察组采用小剂量米非司酮胶囊联合米索前列醇进行治疗。结果：观察组患者腹痛程度、阴道出血情况、宫缩时间与流产时间、流产效果均明显优于对照组，差异有统计学意义（ P＜0�05）；不良反应方面，观察组患者明显轻于对照组，差异有统计学意义（P＜0�05）。结论：与常规剂量相比，小剂量米非司酮联合米索前列醇终止早期妊娠的效果及安全性均更为满意，建议临床推广使用。
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