目的:探讨三维适形放疗联合化疗同步治疗非小细胞肺癌晚期局部复发的疗效.方法:选取2016年2月至2017年9月湖北省罗田县人民医院收治的非小细胞肺癌晚期局部复发患者80例进行回顾性分析,根据治疗方式的不同分为观察组和对照组,每组40例.对照组患者采用三维适形放疗治疗,观察组患者采用三维适形放疗+化疗同步治疗.观察两组患者的生存情况、不良反应发生情况.结果:随访6个月、1年时,观察组患者的生存率分别为82.50％(33/40)、62.50％(25/40),明显高于对照组的57.50％(23/40)、30.00％(12/40),差异均有统计学意义(P＜0.05).观察组患者的不良反应发生率为10.00％(4/40),明显低于对照组的30.00％(12/40),差异有统计学意义(P＜0.05).结论:三维适形放疗联合化疗同步治疗非小细胞肺癌晚期局部复发,可提高患者的生存率,且不良反应较少.%OBJECTIVE: To probe into the efficacy of three dimensional conformal radiation therapy combined with synchronous chemotherapy in treatment of local recurrence of advanced non small cell lung cancer (NSCLC). METHODS: 80 patients with local recurrence of advanced NSCLC admitted into People's Hospital of Hubei Luotian County from Feb. 2016 to Sept. 2017 were retrospectively analyzed and divided into observation group and control group according to different treatments, with 40 cases in each. The control group was given three dimensional conformal radiation therapy, while the observation group was given three dimensional conformal radiation therapy combined with chemotherapy for synchronizing treatment. The survival rates and incidences of adverse drug reactions of two groups were observed. RESULTS: At the follow-up pf 6 month and 1 year, the survival rates of observation group were respectively 82.50％ (33/40) and 62.50％ (25/40), which were significantly higher than those of the control group (57.50％, 23/40; 30.00％, 12/40), with statistically significant differences (P＜0.05). The incidence of adverse drug reactions of observation group was 10.00％ (4/40), which was significantly lower than that of the control group (30.00％, 12/40), with statistically significant difference (P＜0.05). CONCLUSIONS: The combination of three dimensional conformal radiation therapy and synchronous chemotherapy in treatment of local recurrence of NSCLC can improve patients' survival rates, with few adverse drug reactions.
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