为建立化妆品中18种磺胺类相关化合物的 LC-MS/MS 测定法,将样品用丙酮提取,经 SPE 固相萃取柱净化富集,在 C18色谱柱(4.6 mm ×50 mm ×2.7μm)上以甲醇-0.1%(体积分数)甲酸水溶液为流动相梯度洗脱,在 ESI 正离子 MRM 模式下检测。结果发现:18种化合物在10~800 ng/mL 的质量浓度范围内线性关系良好,加标回收率为78.6%~97.2%,检出限为25μg/kg。%A LC-MS/MS method for determination of 18 kinds of sulfonamide residues in cosmetics was established.The sample was extracted by acetone,then purified by SPE.The chromatographic separation was carried out on a C18 column (4.6 mm × 50 mm × 2.7 μm ).Mixture of methanol and 0.1 %(volume fraction)formic acid-water solution was used as mo-bile phase for gradient elution.The tests were carried out in the ESI positive ion MRM mode.The results showed that the line-arity ranged from 10 to 800 ng/mL,all recoveries were between 78.6% to 97.2%,the limit of detection was 25 μg/kg.
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