An ultra-performance liquid chromatography with tandem mass spectrometry method for determination of bisphenol A diglycidyl ether （BADGE） , novolac glycidyl ether （NOGE） and its derivatives from canned food has been developed. The proposed method includes microwave-assisted extraction followed by puri？ cation by solid phase extraction （SPE）. After separation by BEH Cls （ column 100 mm ×2.1 mm, 1.7 μm）, the sample was detected by API 4000 - QTRAP mass spectrometry under positive electrospray ionization mode, with acetonitrile and 0.2% aqueous formic acid as mobile phase. The detection limits were 0. 010 2 - 0. 197 2 ng/g, and recoveries at three different concentrations ranged from 65.7% to 99. 1%. This method was successfully applied to canned fish and meat, the highest total contents of 3 -6 R-NOGE reached 209.03 mg/6 dm2.%建立了一种罐头食品中的BADGE（bisphenol A diglycidyl ether，双酚A-二环氧甘油醚）、NOGE（novolac glycidyl ether，酚醛清漆甘油醚）及其衍生物含量的超高效液相色谱-串联质谱检测法。前处理包括正己烷／丙酮微波辅助萃取，Varain-PS-DVB固相萃取柱净化等。样品经BEH C18色谱柱（100mm×2．1mm，1．7μm）分离，以乙腈和0．2％甲酸水为流动相，进行梯度洗脱，在API4000-Q TRAP质谱仪电喷雾正离子、多反应监测（MRM）模式下进行检测。分析物检出限达到0．0102ng／g到0．1972ng／g，三水平加标回收率在65．7％～99．1％。
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