The extraction process for Datura stramonium L. total alkaloids by the method of alcohol refluxing was optimized. Four process conditions including extraction temperature and time,alcohol concentrationand, solid/solvent ratio were investigated for their effect on the extraction efficiency of Datura stramonium L.total al-kaloids and optimized using an L9 (34) orthogonal array design. Results showed that the optimal extraction conditions were extraction temperature of 60℃,extraction time of 2 h ,alcohol concentration 75%,and solid/solvent ratio of 1∶15 (g/mL).%采用乙醇回流法提取曼陀罗总生物碱，并对提取条件进行优化。首先采用单因素试验考察料液比、提取时间、提取温度、pH等因素对曼陀罗总生物碱提取效果的影响，再以此四因素进行L9（34）正交试验以确定最佳工艺条件。结果表明：曼陀罗中总生物碱的最佳提取工艺条件为提取温度60℃、提取时间2 h、提取剂乙醇浓度75%、料液比1∶15（g/mL）。
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