The acute toxicity of the four aquacultural drugs to Paramisgurnus dabryanus’fingerling [body weight (1.53 ± 0.32 g)] was tested under the hydrostatic conditions.The results showed that the LC50(24, 48 and 96 h) of copper sulfate were 1.23, 0.55 and 0.40 mg/L, respectively, and the safety concentration was 0.03 mg/L.The LC50 (24, 48 and 96 h) of PVP-I were 429.58, 396.36 and 388.47 mg/L, respectively, and the safety concentration was 101.23 mg/L.The LC50 (24, 48 and 96 h) of trichlorfon were 16.72, 7.94 and 4.80 mg/L, respectively, and the safety concentration was 0.54 mg/L.The LC50 (24, 48 and 96 h) of formaldehyde were 110.00, 96.59 and 45.45 mg/L, respectively, and the safety concentration was 22.35 mg/L.In conclusion, copper sulfate was limited to be used due to high toxicity and the safe-ty concentration was much lower than the common concentration, trichlorfon should be used cautiously in common concen-tration, PVP-I and formaldehyde could be used to control the corresponding diseases of Paramisgurnus dabryanus.%以规格（1.53±0.32） g重的大鳞副泥鳅（Paramisgurnus dabryanus）苗种为试验对象，采用静态急性毒性试验法，进行了硫酸铜、聚维酮碘、敌百虫、甲醛的急性毒性试验。结果表明，硫酸铜24、48、96 h的半致死量分别为1.23、0.55、0.40 mg／L，安全浓度为0.03 mg／L；聚维酮碘24、48、96 h的半致死量分别为429.58、396.36、388.47 mg／L，安全浓度为101.23 mg／L；敌百虫24、48、96 h 的半致死量分别为16.72、7.94、4.80 mg／L，安全浓度为0.54 mg／L；甲醛24、48、96 h的半致死量分别为110.00、96.59、45.45 mg／L，安全浓度为22.35 mg／L。结论：硫酸铜的毒性最大且安全浓度远低于常用浓度，应禁用；敌百虫的安全浓度处于常用浓度范围内，但使用时需控制使用剂量；聚维酮碘和甲醛可按常规浓度安全使用。
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