The growth hormone gene ( GH) affects animal growth and is a potential target for genetic studies of variation re-lated to growth traits.In this study, 315 Gansu golden trout were collected to study the single nucleotide polymorphisms (SNPs) in GH exon regions and their associations with growth traits using PCR -SSCP.The results showed that it was site mutations G/C existed at the 903 bp in allele B, there are three kinds of genotype AA , AB, and BB.There were site mu-tations C/A and T/G existed at the 3 049 bp and 3 094 bp in allele D, respectively, and the second site mutation at 3 094 bp which caused histidine to transform into glutamine was sense mutation , there were three haplotypes , named CC, DD and CD.The result of Least Squares analysis showed that: total length and body length of BB type was significantly higher than types AA and AB ( P<0.05 ).The CC genotype had a significantly positive correlation with total length , body length and body weight ( P<0.05 ) , those of CC were higher than types DD and CD.These basic data highlight the potential for using GH as a genetic marker of fish growth in marker assisted selection.%生长激素（ GH）基因能够影响动物的生长，是一个与生长性状有关的基因。以315尾甘肃金鳟（ Oncorhyn-chus mykiss）为研究材料，分析了GH基因外显子区域多态性，并对基因型与生长性状进行了关联性分析。 PCR-SSCP分析结果显示B等位基因在外显子2区域第903 bp处发生G/C突变，存在3种基因型AA、 AB和BB。 D等位基因在外显子5区域第3049 bp处发生T/G的突变，在3094 bp处发生C/A的突变，其中第3049 bp处发生的T/G的突变导致第157位氨基酸由组氨酸变为谷氨酰胺，为有义突变，共检测到3种基因型CC、 CD和DD个体。最小二乘法分析表明， BB基因型的全长值和体长值都显著高于AA和AB基因型（ P＜0.05）。 T3049 G和C3094 A突变点对全长、体长和体重均有显著性影响（ P＜0.05），其中CC基因型的全长值、体长值和体重值都高于DD和CD基因型。在标记辅助育种中，这些分子标记可以为甘肃金鳟遗传改良提供基础的数据和参考。
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