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首页> 中文期刊> 《基因组蛋白质组与生物信息学报：英文版》 >KaKs_Calculator:Calculating Ka and Ks Through Model Selection and Model Averaging

KaKs_Calculator:Calculating Ka and Ks Through Model Selection and Model Averaging

         
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摘要

KaKs_Calculator is a software package that calculates nonsynonymous (Ka) andsynonymous (Ks) substitution rates through model selection and model averag-ing. Since existing methods for this estimation adopt their specific mutation(substitution) models that consider different evolutionary features, leading todiverse estimates, KaKs Calculator implements a set of candidate models in amaximum likelihood framework and adopts the Akaike information criterion tomeasure fitness between models and data, aiming to include as many featuresas needed for accurately capturing evolutionary information in protein-coding se-quences. In addition, several existing methods for calculating Ka and Ks arealso incorporated into this software. KaKs Calculator, including source codes,compiled executables, and documentation, is freely available for academic use athttp://evolution.genomics.org.cn/software.htm.

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