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首页> 中文期刊> 《基因组蛋白质组与生物信息学报：英文版》 >Landscape and Dynamics of the Transcriptional Regulatory Network During Natural Killer Cell Differentiation

Landscape and Dynamics of the Transcriptional Regulatory Network During Natural Killer Cell Differentiation

         
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摘要

Natural killer（NK） cells are essential in controlling cancer and infection. However, little is known about the dynamics of the transcriptional regulatory machinery during NK cell differentiation. In this study, we applied the assay of transposase accessible chromatin with sequencing（ATAC-seq） technique in a home-developed in vitro NK cell differentiation system. Analysis of ATAC-seq data illustrated two distinct transcription factor（TF） clusters that dynamically regulate NK cell differentiation. Moreover, two TFs from the second cluster, FOS-like 2（FOSL2） and early growth response 2（EGR2）, were identified as novel essential TFs that control NK cell maturation and function. Knocking down either of these two TFs significantly impacted NK cell differentiation. Finally, we constructed a genome-wide transcriptional regulatory network that provides a better understanding of the regulatory dynamics during NK cell differentiation.

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