Different Gene Networks Are Disturbed by Zika Virus Infection in A Mouse Microcephaly Model

Yafei Chang; Yisheng Jiang; Cui Li; Qin Wang; Feng Zhang; Cheng-Feng Qin; Qing-Feng Wu; Jing Li; Zhiheng Xu

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Different Gene Networks Are Disturbed by Zika Virus Infection in A Mouse Microcephaly Model

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The association of Zika virus（ZIKV） infection with microcephaly has raised alarm worldwide. Their causal link has been confirmed in different animal models infected by ZIKV.However, the molecular mechanisms underlying ZIKV pathogenesis are far from clear. Hence,we performed global gene expression analysis of ZIKV-infected mouse brains to unveil the biological and molecular networks underpinning microcephaly. We found significant dysregulation of the sub-networks associated with brain development, immune response, cell death, microglial cell activation, and autophagy amongst others. We provided detailed analysis of the related complicated gene networks and the links between them. Additionally, we analyzed the signaling pathways that were likely to be involved. This report provides systemic insights into not only the pathogenesis,but also a path to the development of prophylactic and therapeutic strategies against ZIKV infection.

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《基因组蛋白质组与生物信息学报：英文版》 |2020年第6期|737-748|共12页
作者
Yafei Chang; Yisheng Jiang; Cui Li; Qin Wang; Feng Zhang; Cheng-Feng Qin; Qing-Feng Wu; Jing Li; Zhiheng Xu;
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作者单位

1. Department of Bioinformatics and Biostatistics;

School of Life Sciences and Biotechnology;

Shanghai Jiao Tong University 2. State Key Laboratory of Molecular Developmental Biology;

CAS Center for Excellence in Brain Science and Intelligence Technology;

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正文语种 chi
中图分类病毒传染病;
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Different Gene Networks Are Disturbed by Zika Virus Infection in A Mouse Microcephaly Model

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