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首页> 中文期刊> 《安徽地质》 >Photosensitizer Nanoparticles Boost Photodynamic Therapy for Pancreatic Cancer Treatment

Photosensitizer Nanoparticles Boost Photodynamic Therapy for Pancreatic Cancer Treatment

         
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摘要

Patients with pancreatic cancer(PCa)have a poor prognosis apart from the few suitable for surgery.Photodynamic therapy(PDT)is a minimally invasive treatment modality whose efficacy and safety in treating unresectable localized PCa have been corroborated in clinic.Yet,it suffers from certain limitations during clinical exploitation,including insufficient photosensitizers(PSs)delivery,tumor-oxygenation dependency,and treatment escape of aggressive tumors.To overcome these obstacles,an increasing number of researchers are currently on a quest to develop photosensitizer nanoparticles(NPs)by the use of a variety of nanocarrier systems to improve cellular uptake and biodistribution of photosensitizers.Encapsulation of PSs with NPs endows them significantly higher accumulation within PCa tumors due to the increased solubility and stability in blood circulation.A number of approaches have been explored to produce NPs co-delivering multi-agents affording PDT-based synergistic therapies for improved response rates and durability of response after treatment.This review provides an overview of available data regarding the design,methodology,and oncological outcome of the innovative NPs-based PDT of PCa.

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  • 来源
    《安徽地质》 |2021年第2期|246-261|共16页
  • 作者

    Huanyu Yang; Renfa Liu; Yunxue Xu; Linxue Qian; Zhifei Dai;

  • 作者单位

    Department of Ultrasound Beijing Friendship Hospital Capital Medical University No. 95 Yongan Road Xicheng District Beijing 100050 People's Republic of China;

    Department of Biomedical Engineering College of Engineering Peking University No. 5 Yiheyuan Road Haidian District Beijing 100871 People's Republic of China;

    Department of Biomedical Engineering College of Engineering Peking University No. 5 Yiheyuan Road Haidian District Beijing 100871 People's Republic of China;

    Department of Ultrasound Beijing Friendship Hospital Capital Medical University No. 95 Yongan Road Xicheng District Beijing 100050 People's Republic of China;

    Department of Biomedical Engineering College of Engineering Peking University No. 5 Yiheyuan Road Haidian District Beijing 100871 People's Republic of China;

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