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首页> 中文期刊> 《环球中医药》 >保肾通络方对早期糖尿病肾病大鼠尿蛋白及尿Nephrin、Podocin排泄的影响

保肾通络方对早期糖尿病肾病大鼠尿蛋白及尿Nephrin、Podocin排泄的影响

         
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摘要

目的 观察不同剂量的保肾通络方对早期糖尿病肾病大鼠尿蛋白、尿 Nephrin、尿Podocin排泄的影响,探讨本方对糖尿病肾病的作用机制及最佳剂量.方法 将链脲佐菌素(streptozocin,STZ)建立的早期糖尿病肾病大鼠模型随机分为正常组、模型组及中药高、中、低剂量组.用药8周后,检测各组大鼠血糖、尿糖、尿白蛋白及尿Nephrin、Podocin的水平,并将尿Nephrin、Podocin的排泄浓度与尿白蛋白做相关性分析.结果 药物干预8周后,中药各剂量组大鼠的血糖、尿糖、尿白蛋白水平较模型组有降低趋势,但组间差异无统计学意义(P>0.05);中药各剂量组大鼠尿Nephrin、Podocin排泄均低于模型组,其中中药中剂量组、中药高剂量组尿Nephrin排泄明显低于模型组(P<0.05),但二者组间差异无统计学意义(P>0.05);Pearson相关分析显示尿Nephrin、尿Podocin排泄呈正相关(r=0.517,P<0.05),且二者均与尿白蛋白水平呈正相关(r=0.746,P<0.05).结论 保肾通络方对早期糖尿病肾病大鼠足细胞可能存在保护作用,其中对尿Nephrin排泄的影响可能先于尿白蛋白出现.%Objective To observe the effects of different doses of Baoshen Tongluo recipe on urinary protein,urinary nephrin、podocin excretion in early diabetic nephropathy rats, and investigate its protection of diabetic nephropathy and the optimal dose. Methods Early diabetic nephropathy rats model was induced by streptozotocin(STZ),and the rats were randomly divided into normal group, model group and different dose traditional Chinese medicine groups. After treatment for 8 weeks, blood glucose, urine glucose,urinary albumin and urinary excretion of nephrin、podocin were detected, and correlation analysis was conducted between the concentration of nephrin and podocin in urine and urinary albumin. Results After 8 weeks of drug intervention,the levels of blood glucose, urine glucose,urinary albumin in different dose of Chinese medicine group were lower than those of model group, but there were no significant differences among intervention groups(P>0.05). The urinary nephrin and podocin excretion in traditional Chinese medicine groups were lower than those in the model group,and the excretion of urinary nephrin in high and middle dose of traditional Chinese medicine groups were significantly lower than that of model group(P＜0.05),but there were no differences between the high dose group and middle dose group of tra-ditional Chinese medicine. Pearson correlation analysis showed that urinary nephrin, urinary podocin excretion was positively correlated (r=0.517,P＜0.05), and two of them were positively correlated with urinary protein level (r=0.746, P＜0.05). Conclusion Baoshen Tongluo recipe may have protective effect on glomerular podocyte in rats with early diabetic nephropathy,the effect on urinary nephrin excretion may be prior to urinary albumin excretion.

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  • 来源
    《环球中医药》 |2017年第12期|1423-1427|共5页
  • 作者

    唐珑; 申子龙; 王悦芬; 赵文景; 孙雪艳; 崔方强; 孟元; 赵静; 蔡朕; 王晖;

  • 作者单位

    100010 首都医科大学附属北京中医医院肾病科;

    100010 首都医科大学附属北京中医医院肾病科;

    100010 首都医科大学附属北京中医医院肾病科;

    100010 首都医科大学附属北京中医医院肾病科;

    100010 首都医科大学附属北京中医医院肾病科;

    100010 首都医科大学附属北京中医医院肾病科;

    100010 首都医科大学附属北京中医医院肾病科;

    100010 首都医科大学附属北京中医医院肾病科;

    100010 首都医科大学附属北京中医医院肾病科;

    100010 首都医科大学附属北京中医医院肾病科;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 糖尿病;
  • 关键词

    糖尿病肾病; 保肾通络方; 尿Nephrin; 尿Podocin; 足细胞;

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