Production of a novel non-toxicγ-PGA/casein composite hydrogel using MTG and optimization by response surface methodology

Xin Wang; Chenchen Gou; Chunyuan Gao; Yazhen Song; Jinming Zhang; Dandan Zhai; Yawei Zhao; Jihong Huang; Ming Hui

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Production of a novel non-toxicγ-PGA/casein composite hydrogel using MTG and optimization by response surface methodology

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摘要

Theγ-PGA-based food hydrogel exhibits good biodegradability and biocompatibility,and is non-toxic to humans.In this study,a novel hydrogel(γ-PGA/casein composite hydrogel)was prepared by combining casein with y-PGA separated from natto using microbial transglutaminase(MTG)as the crosslinker.The effects of the MTG mass concentration,gelation time,crosslinking temperature,pH,and the mass ratio of y-PGA to casein on the crosslinking ratio of y-PGA and swelling ratio of theγ-PGA/casein hydrogel were investigated.Furthermore,the synthesis conditions were optimized by response surface methodology to optimize three important factors,i.e.crosslinking temperature,pH and the mass ratio of y-PGA to casein.The results of single factor experiments showed that the MTG mass concentration and crosslinking time had little impacts on the crosslinking ratio of y-PGA and the swelling ratio;the preferred MTG mass concentration,crosslinking time,temperature and pH were selected as 0.3%,7 h,40°Cand 7.5;and the preferred mass ratio ofγ-PGA to casein was 0.1 for the crosslinking ratio ofγ-PGA and 0.2 for the swelling ratio.The response surface experiment results showed that the optimum crosslinking temperature,pH and the mass ratio of y-PGA to casein ratio were 42.4°C,7.33,and 0.18,respectively.Under these optimum conditions,the predicted crosslinking ratio of y-PGA and swelling ratio reached 90.35%and 112.07%,which were highly consistent with the experimental values(88.00%and 115.87%).Theγ-PGA/casein composite hydrogel developed in this study shows promising application potential in food industry,biomedical field,and cosmetic industry.

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《粮油科技：英文版》 |2021年第2期|P.71-80|共10页
作者
Xin Wang; Chenchen Gou; Chunyuan Gao; Yazhen Song; Jinming Zhang; Dandan Zhai; Yawei Zhao; Jihong Huang; Ming Hui;
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作者单位

College of Biological Engineering Henan University of Technology Zhengshou 450001 China;

College of Biological Engineering Henan University of Technology Zhengshou 450001 China;

College of Biological Engineering Henan University of Technology Zhengshou 450001 China;

College of Biological Engineering Henan University of Technology Zhengshou 450001 China;

College of Biological Engineering Henan University of Technology Zhengshou 450001 China;

College of Biological Engineering Henan University of Technology Zhengshou 450001 China;

College of Biological Engineering Henan University of Technology Zhengshou 450001 China;

College of Biological Engineering Henan University of Technology Zhengshou 450001 China;

College of Biological Engineering Henan University of Technology Zhengshou 450001 China;

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原文格式 PDF
正文语种 chi
中图分类高分子化学（高聚物）;
关键词
Hydrogel synthesis; MTG cross-linking; y-PGA; Casein; Composite hydrogel;

机译：水凝胶合成;MTG交联;Y-PGA;酪蛋白;复合水凝胶;

Production of a novel non-toxicγ-PGA/casein composite hydrogel using MTG and optimization by response surface methodology

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