Objective To investigated the serum AOPP levels , and the correlation betweenAOPP and the activity of lupus nephritis (LN).Methods Twenty-nine LN patients were included in LN group , and 21 age, weight and gen-der-matched controls were also included .The 29 LN patients were further divided into eGFR≥60 group and eGFR<60 group according to eGFR .The Scr, BUN, ALB, ESR, CRP, C3, C4, 24hUPQ and eGFR were evaluated in all subjects . The levels of AOPP , MDA, and anti-dsDNA were detected with ELISA .LN activity wasevaluated according to SLE dis-ease activity index .Results The LN group exhibited significantly higher CRP , ESR, 24hUPQ, anti-dsDNA, AOPP, and MDA levels, but lower C3, C4, and eGFRcompared to those in controls (P<0.05).In eGFR<60 subgroup, signif-icantly higher ESR , MDA was revealed whencompared to those in eGFR≥60 subgroup ( P<0.05 ) .Serum AOPP was significantly positively correlated with MDA (r=0.942, P<0.05), anti-dsDNA (r=0.982, P<0.05), and SLEDAI scores (r=0.653, P<0.05);but negatively correlated with eGFR (r=-0.298, P<0.05).Conclusion The serum AOPP levels are evaluated in LN patients .And AOPP increases with the progression of renal dysfunction .AOPP is a bio-logical marker that reflects oxidative stress in LN patients .Higher serum AOPPis correlated with LN disease activity .%目的：探讨氧化应激标志物晚期蛋白氧化产物（ AOPP）在狼疮肾炎（ LN）患者血清水平变化及其与LN疾病活动的相关性。方法 LN患者29例，根据肾小球滤过率（eGFR）水平分为eGFR≥60 mL／（min·1.73 m2）组16例、eGFR＜60 mL／（ min·1.73 m2）组13例。同期选择性别、年龄、体重匹配的健康对照者21例（对照组），测定各组血肌酐（Scr）、尿素氮（BUN）、血白蛋白（ALB）、血沉（ESR）、C反应蛋白（CRP）、补体C3、C4以及24 h尿蛋白定量（24hUPQ）、eGFR；ELISA法测定各组患者的AOPP、丙二醛（ MDA）、抗dsDNA抗体；运用系统性红斑狼疮（SLE）疾病活动指数（SLEDAI）积分表对LN患者的疾病活动性进行评分。结果 LN组患者CRP、ESR、24hUPQ、抗dsDNA抗体、AOPP、MDA均较对照组明显升高，差异有统计学意义（P＜0.05），C3、C4、eGFR较对照组降低，差异有统计学意义（P＜0.05）；LN患者eGFR＜60组ESR、MDA较eGFR≥60组明显升高，差异有统计学意义（P＜0.05）；而CRP、AOPP、抗dsDNA抗体、SLEDAI积分、24hUPQ均较eGFR≥60组升高，但差异无统计学意义（P＞0.05）；血清AOPP与MDA呈显著正相关（r＝0.942，P＜0.05），与抗dsDNA抗体呈显著正相关（r＝0.982，P＜0.05），与SLEDAI积分呈正相关（r＝0.653，P＜0.05），与eGFR呈负相关（r＝－0.298，P＜0.05）。结论 LN患者血清AOPP水平明显升高，且随着肾功能损害而进一步升高，可作为一种评估LN氧化应激状态的指标。 AOPP与LN疾病活动性密切相关。
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