Objective To investigate the correlation between prenatal fever and neonatal hypoxic - ischemic en-cephalopathy ( HIE ). Methods Maternal fever and other data during pregnancy were recorded from 12 845 pregnant females. Retrospective cohort study was performed, while 897 cases with maternal fever over 38. 5℃ and 571 cases with maternal fever lower than 38. 5℃ were assigned into high fever group and low fever group, respectively. Meanwhile, 816 cases with maternal fever lasting less than 24 h and 652 cases with maternal fever lasting longer than 24 h were assigned into short time group and long time group, respectively. Furthermore, 900 matched cases without maternal fever were selected as control group. Logistic regression model was adopted in the analysis. Results The incidence of maternal fever during pregnancies was 11. 4%. The incidences of HIE in high fever group, low fever group, and long time group, were significantly higher than that in control group, so were in logistic regression model adjusted with confounders. Conclusion Prenatal fever during pregnancy is a human teratogen. We should actively prevent prenatal fever, and select scientific and rational treatment for the fever as soon as possible to reduce the risk of HIE.%目的 探讨产前发热对新生儿缺氧缺血性脑病(HIE)发生的影响.方法 分析12 845例在妇产科分娩的产妇的孕期发热和一般情况资料,据产前1周体温38.5℃和持续时间24 h为界,将1 468例产前1周内有发热史的产妇分为高热组和低热组、短时间组和长时间组,并从同期孕期无发热史的产妇中抽取900例作为对照组.采用logistic回归分析,分析产前发热与新生儿HIE之间的相关性.结果 产前1周有发热史的产妇占产妇总数的11.4%;与对照组相比,低热组、高热组和长时间组的新生儿HIE的发生率均显著升高,即使在控制了潜在混杂因素之后差异仍有统计学意义;但未发现该病的发生与持续时间<24 h的发热有相关性.结论 产前发热可引起新生儿HIE的发生.应积极预防治疗产前发热,使体温尽快下降,从而降低新生儿HIE发生的风险.
展开▼
