Objective To study the relationship between serum nitric oxide (NO) level and spontaneous abortion. Methods Serum NO was determined by Griess reation in 25 cases of nonpregnancy, 25 normal trimester and 25 spontaneous abortion. Results Serum NO in early pregnancy is higher than that of nonpregnancy ( P < 0.01 ). Serum NO in Spontaneous abortion is significantly higher than that of normal trimester (P<0.01). Conclusion Serum NO level increases during pregnancy to maintain the placental barrier funtion and maintain the quiescence of pregnant uterus. Abnormal elevation in serum NO level in the early pregnancy, is cytotoxic and arrests the cell growing, which may leading to spontsneous abortion. Administration of NO synthase inhibifor can avoid the occurence of abortion.On the contrary NO donor may help to terminate of pregnancy in the first trimester.%目的探讨早期自然流产妇女血清一氧化氮(NO)含量变化与自然流产的关系。方法应用酶法分别测定并比较正常妇女、早孕妇女、早期自然流产妇女静脉血中NO的含量。结果早孕妇女血清NO水平较正常妇女血清NO升高(P<0.01)，自然流产妇女NO水平明显高于早孕妇女(P<0.01)。结论妊娠早期NO水平异常升高，可产生细胞毒作用，导致自然流产发生。应用NO抑制剂可避免自然流产；反之，如使用NO供体则有助于终止妊娠。
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