目的 探讨天麻素对癫痫患者炎症因子、脑源性神经营养因子(BDNF)水平的影响.方法 选取120例癫痫患者,随机分为观察组与对照组各60例.对照组服用卡马西平治疗,观察组同时服用卡马西平和天麻素治疗.治疗2个月后,比较两组肿瘤坏死因子α(TNF-ɑ)、白细胞介素-6(IL-6)、C反应蛋白(CRP)及BDNF的表达水平.结果 治疗2个月后,观察组TNF-ɑ、IL-6、CRP水平均低于对照组(P<0.05),BDNF水平高于对照组(P<0.05).两组的不良反应发生率比较差异无统计学意义(P>0.05).结论 天麻素联合卡马西平治疗癫痫可有效降低患者炎症因子水平,并能提高BDNF水平,临床上可用于癫痫的辅助治疗.%Objective To investigate the effect of gastrodin on the levels of inflammatory factors and brain-derived neurotrophic factor ( BDNF) in patients with epilepsy .Methods A total of 120 patients with epilepsy were randomly divided into observation group or control group,with 60 cases in each group .The control group was treated with carbamazepine ,and the observation group with both carbamazepine and gastrodin.After 2 months of treatment,the expression levels of tumor necrosis factor-alpha(TNF-α),interleukin-6(IL-6),C-reactive protein (CRP),and BDNF were compared between the two groups .Results After 2 months of treatment,the levels of TNF-α,IL-6,and CRP were significantly lower,and the level of BDNF was significantly higher in the observation group compared to the control group (P<0.05).There was no significant difference in the incident rate of adverse effects between two groups (P>0.05).Conclusion The combination of gastrodin with carbamazepine can effectively reduce the levels of inflammatory factors ,and increase the level of BDNF .This approach can be applied to the clinical adjuvant therapy of epilepsy .
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