Objective To investigate the effect of Guangxinqi capsule on the immune function of immunosuppressed mice.Methods Sixty mice were randomly divided into blank control group ,model group,positive control group,and high-, medium-and low-dose Guangxinqi groups ,10 mice in each group .The mice in the blank control group and model group were given normal saline ,in the positive control group were given levamisole (25 mg/kg),in the high-,medium-,and low-dose Guangxinqi groups were given Guangxinqi capsule at doses of 1 800 mg/kg,900 mg/kg,and 450 mg/kg,respectively. The mice were fed by gavage with gastric volume 10 ml/kg for 14 days.In order to establish immunocompromised mice model,the mice in the high-,medium-,and low-dose Guangxinqi groups ,model group and positive control group were given intraperitoneal injection with cyclophosphamide of 80 mg/kg on the 10th day,11th day,12th day and 13th day after Guangxinqi administration ,while the mice in the blank control group were injected with normal saline .Then the thymus,spleen weights were measured and the indexes were calculated .Carbon clearance method was used to detect monocyte-macrophage phagocytosis , and colorimetric method was used to detect serum hemolysin content for humoral immune function tests .Results The thymus and speen indexes improved significantly in the high-, medium-, and low-dose Guangxinqi groups in contrast with those in the model group (P<0.05).The carbon clearance rate ,phagocytic index and serum hemolysin level increased significantly in the high-,medium-,and low-dose Guangxinqi groups(P<0.05). No significant difference was found among the three Guangxinqi groups with respected to the immune function ( P>0.05). Conclusion Guangxinqi capsule can improve immune function in the immunosuppressed mice ,which does not show a dose-independent relationship in the dose range .%目的：探讨光新奇胶囊对免疫功能低下小鼠免疫功能的影响。方法60只实验小鼠按随机数字表法分为空白组、模型组、阳性对照组及高、中、低剂量组，每组10只。空白组与模型组给予生理盐水灌胃，阳性对照组给予25 mg／kg的左旋咪唑溶液灌胃，高、中、低剂量组给予光新奇胶囊1800 mg／kg，900 mg／kg，450 mg／kg灌胃，各组灌胃体积均为10 ml／kg，连续灌胃14 d。高、中、低剂量组、模型组与阳性对照组均在给药的第10天、第11天、第12天、第13天腹腔注射环磷酰胺80 mg／kg ，建立小鼠免疫功能低下模型，空白组注射生理盐水。测定胸腺、脾脏重量并计算脏器指数，碳粒廓清法测定单核巨噬细胞吞噬功能，比色法测定血清溶血素水平进行免疫功能试验。结果与模型组相比，光新奇胶囊高、中、低剂量组均能显著提高免疫抑制小鼠的胸腺指数、脾脏指数（P＜0．05）。高、中、低剂量组均能显著升高小鼠碳粒廓清率、吞噬指数及血清溶血素水平（P＜0．05）。3个剂量组各免疫功能指标差异无统计学意义（P＞0．05）。结论光新奇胶囊具有增强免疫抑制小鼠免疫功能的作用，在剂量范围内未发现剂量依赖关系。
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