[Abstrat] Objective To investigate Doxofylline the treatment of chronic obstructive pulmonary disease efifcacy, safety, in order to improve the quality of clinical treatment. Methods A retrospective analysis of patients with chronic obstructive pulmonary disease patients in March 2010 to March 2013, divided into two groups, the control group with 5%glucose injection 250 mL intravenous infusion of aminophylline injection 250 mg, the observation group to be of doxofylline 100 mL intravenous infusion, the two groups were compared efifcacy and safety. Results The control group 3 days and one week in cough, sputum, wheezing, wheeze improvement rates were 31.7%, 41.2%, 47.7%, 30.2%and 82.9%, 79.4%, 81.8%, 79.1%;the observation group 3 days and one week in the control group cough, sputum, wheezing, wheeze improvement rates were 70%, 68.6%, 65.9%, 76.2%and 97.5%, 94.3%, 95.4%, 92.9%. Both groups had signiifcant difference (P<0.05);from the overall clinical effect of the control group, the total effective rate was 84.4%, the effective rate was 97.8%in the observation group, the two groups there are differences (P<0.05 );before and after treatment in IL-1, INF-alpha, IL-8, IL-10, PaO2, PaCO2 comparison has improved, but the observation group than the control group there are signiifcant differences (P<0.05);control group the overall incidence of adverse reactions was 44.4%, the observation group, the incidence of adverse reactions was 6.6%, the difference was significantly (P<0.05), above circumstances were statistically signiifcant. Conclusion Doxofylline treatment of chronic obstructive pulmonary disease effect is remarkable, safe.%目的：探讨多索茶碱治疗慢性阻塞性肺疾病的有效性、安全性，以期提高临床治疗质量。方法回顾性分析2010年3月至2013年3月90例慢性阻塞性肺疾病患者，分成2组，对照组采用氨茶碱注射液250 mg配5%葡萄糖注射液250 mL静脉滴注，观察组予以多索茶碱100 mL静脉滴注，比较两组的有效性和安全性。结果对照组3 d和1周在咳嗽、咳痰、喘息、哮鸣音上的改善率分别为31.7%、41.2%、47.7%、30.2%和82.9%、79.4%、81.8%、79.1%；而观察组治疗3 d和1周对照组在咳嗽、咳痰、喘息、哮鸣音上的改善率分别为70%、68.6%、65.9%、76.2%和97.5%、94.3%、95.4%、92.9%。两组有明显的差异性（P＜0.05）；而从总的临床效果看，对照组总的有效率为84.4%，观察组的有效率为97.8%，两组比较也有差异性（P＜0.05）；两组治疗前后在IL-1、INF-α、IL-8、IL-10、PaO2、PaCO2比较上有改善，但观察组较对照组有明显的差异性（P＜0.05）；对照组总的不良反应发生率为44.4%，观察组的不良反应发生率为6.6%，两组比较差异性明显（P＜0.05），以上情况均有统计学意义。结论多索茶碱治疗慢性阻塞性肺疾病的有效效果显著，安全性高。
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