目的：分析窒息后肾功能损害新生儿的阴离子间隙(AG)变化及其与肾损害的关系。方法首先测定151例窒息新生儿的血尿素氮（BUN）、肌酐（Cr）、电解质、动脉血气分析；然后，从中选取肾损害新生儿60例，并同时测定30例正常足月儿的上述指标，计算AG值并分析。结果窒息后肾损害的60例新生儿，代谢性酸中毒发生率为76.7%，且以高AG代酸为主，随窒息程度的加重，BUN、Cr无明显变化。结论窒息后肾功能损害新生儿血AG值可明显异常，需及时处理，BUN、Cr不能早期反映新生儿肾损害。%Objective To analysis the changes of anion gap (AG) and discuss the relationship between AG and renal function of the neonates with renal injury after asphyxia. Methods Firstly, interval index of serum BUN, Cr, electrolytes, artery blood gas analysis was detected in 151 cases of neonatal asphyxia. Then, 60 cases of neonates with renal injury were selected from them and the same interval index of 30 cases of normal term infants was also detected. The AG value was calculated and analyzed. Results In 60 cases of neonates with renal injury after asphyxia, the incidence of metabolic acidosis was 76.7%, especially metabolic acidosis with high AG. With the severity of asphyxia, serum BUN and Cr made no obvious changes. Conclusion AG in neonates with renal injury after asphyxia changed significantly and should be treated promptly, BUN and Cr were not early indicators of neonates with renal injury.
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