Objective To study the clinical effect of metformin combined with clomiphene in treatment of patients with polycystic ovary syndrome with infertility. Methods 96 cases of patients with polycystic ovary syndrome with infertility in our hospital from 2011 to 2012 were selected, they were randomly divided into two groups, and treated with only clomiphene and metformin combined with clomiphene, the treatment effects of two groups were compared. Results After treatment, the fasting insulin (FINS), follicle stimulating hormone (FSH), fasting blood glucose (FPG), luteinizing hormone (LH), testosterone (T) of the study group were signiifcantly lower than those in the control group, the endometrial thickness of the study group increased signiifcantly comparing to the control group, and the pregnancy rate was signiifcantly better than the control group.Conclusion Metformin combined with clomiphene in treatment of polycystic ovary syndrome with infertility can effectively improve patients with hormone levels, increase endometrial thickness, and effectively improve the pregnancy rate after the treatment, it should be deeply studied.%目的：探讨多囊卵巢综合征合并不孕患者治疗中克罗米芬联合二甲双胍的临床效果。方法选取2011年至2012年我院收治的多囊卵巢综合征合并不孕患者96例，随机分为两组，分别采取单纯克罗米芬治疗和克罗米芬与联合二甲双胍治疗，对比两组治疗效果。结果治疗后研究组患者空腹胰岛素（FINS）、促卵泡激素（FSH）、空腹血糖（FPG）、促黄体激素（LH）、睾酮（T）均明显低于对照组，子宫内膜厚度相比对照组明显增加，妊娠率与显著优于对照组。结论二甲双胍联合克罗米芬治疗多囊卵巢综合征合并不孕能够有效改善患者体内激素水平，增加子宫内膜厚度，有效提高治疗后的妊娠率，应当进一步深入研究。
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