Objective To investigate the effectiveness of biological fibrin glue closure in pregnant women with preterm premature rupture of membrane. Methods Twenty-eight cases of pregnant women with preterm prema-ture rupture of membrane from March 2012 to December 2013 in our hospital were selected and divided into three groups randomly. All three groups were treated with biological fibrin glue closure via the cervical intubation with the monitoring of ultrasound (Group A, 10 cases), endoscopy (Group B, 8 cases) and amnioscopy (Group C, 10 cases). To-colytics were applied as following in all groups. And then the effectiveness and differences in delivery were compared. Results In Group A, the cure rate, effective rate and inefficiency rate were 0.0%(0 case), 20.0%(2 cases) and 80.0%(8 cases) respectively, with 2 cases of natural childbirth, 3 cases of operative vaginal delivery and 5 cases of cesarean section, and the fetal survival rate was 60.0%. In Group B, the cure rate, effective rate and inefficiency rate were 25.0%(2 cases), 50.0%(4 cases) and 25.0%(2 cases) respectively, with 1 case of natural childbirth, 1 case of opera-tive vaginal delivery and 3 cases of cesarean section, and the fetal survival rate was 83.3%. And in Group C, the cure rate, effective rate and inefficiency rate were 80.0%(8 cases), 10.0%(1 case) and 10.0%(1 case), with 8 cases of natu-ral childbirth, 1 case of operative vaginal delivery, 1 case of cesarean section, and the fetal survival rate was 100.0%. The total effective rate in group C was higher than those in group A and B (P<0.05). Meanwhile, compared with other groups, Group C had a longer pregnant period, lower neonatal death rate and less perinatal compilations (P<0.05). Conclusion Biological fibrin glue closure via the cervical intubation with the monitoring of amnioscopy is effective and easy to be manipulated, which can avoid the influence of water injection on the coagulation of biological fibrin glue. Therefore, it's worthy to be recommended.%目的：探讨生物蛋白胶宫颈封堵术治疗未足月胎膜早破的有效性。方法将在我院治疗的28例未足月胎膜早破孕产妇随机分为三组，A组10例采用B超监测下经宫颈插管生物蛋白胶封堵法治疗，B组8例行腔镜介导下宫颈插管推注生物蛋白胶封堵术，C组10例行羊膜镜介导下宫颈插管推注生物蛋白胶封堵胎膜破口术，三组再给予相同的抑制宫缩治疗和护理，比较三组孕产妇的手术效果和分娩差异。结果 A组孕产妇治愈0例(0.0%)，有效2例(20.0%)，无效8例(80.0%)，其中自然分娩2例，人工助产3例，剖宫产5例，胎儿存活率为60.0%；B组孕产妇治愈2例(25.0%)，有效4例(50.0%)，无效2例(25.0%)，其中自然分娩4例，人工助产1例，剖宫产3例，胎儿存活率为83.3%；C组孕产妇治愈8例(80.0%)，有效1例(10.0%)，无效1例(10.0%)，其中自然分娩8例，人工助产1例，剖宫产1例，胎儿存活率为100.0%，治疗效果和术后分娩情况显著优于其他两组，其差异均具有统计学意义(P<0.05)。结论羊膜镜介导下生物蛋白胶封堵胎膜破口法结合了传统方法的优点，封堵成功率高，操作相对简单，而且不需要注水，不影响生物蛋白胶的凝固，值得推广。
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