Objective To study the influence of estrogen and progesterone on the uterine hemodynamics, en-dometrial microvessel density and serum factors in patients with dysfunctional uterine bleeding. Methods Ninety patients with dysfunctional uterine bleeding from March 2010 to October 2011 were selected and randomly divided into control group (treated with progesterone) and observation group (treated with estrogen and progesterone), with 45 cases in each group. The uterine hemodynamics,endometrial microvessel density and serum anti thyroid peroxidase antibody (TPOAb), Inhibin B (INHB), Thromboxane A2/ Prostacyclin (TXA2/PGI2) were compared between two groups before and after the treatment at first and third month. Results The resistance index of observation group after the treatment at first and third month were smaller than those of control group, blood flow.pulsatiliry index, S/D and average velocity were bigger than those of control group, microvessel density and serum TXA2/PGI2, INHB were all higher than those of control group, serum TPOAb were lower than those of control group, all with P<0.05. Conclusion Compared with progesterone, the combination of estrogen and progesterone has more influence on the uterine hemodynamics, endometrial microvessel density and serum factors of patients with dysfunctional uterine bleeding.%目的 探讨雌孕激素对功血患者子宫血流动力学及子宫内膜微血管密度、血清因子的影响.方法 选取2010年3月至2011年10月于本院进行治疗的90例功血患者为研究对象,将其随机分为对照组(孕激素组)和观察组(雌激素联合孕激素组)各45例,将两组患者治疗前及治疗后1个月、3个月的子宫血流动力学及子宫内膜微血管密度、血清抗甲状腺过氧化物酶抗体(TPOAb)、抑制素B(INHB)、血栓素A2/前列环素(TXA2/PGI2)水平进行比较.结果 观察组治疗后1个月、3个月的阻力指数小于对照组,血流量、搏动指数、S/D及平均流速均大于对照组,微血管密度、血清TXA2/PGI2及INHB高于对照组,血清TPOAb低于对照组(P均＜0.05),差异有统计学意义.结论 雌孕激素对功血患者子宫血流动力学及子宫内膜微血管密度、血清因子的影响均大于单纯采用孕激素治疗,因此认为其应用价值更高.
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