目的：探讨美多巴联合盐酸普拉克索治疗帕金森病患者（ Parkinson's disease，PD）的临床疗效，并观察和分析其对运动功能的影响。方法146例PD患者随机分为对照组和观察组各73例，对照组患者应用美多巴进行治疗，观察组应用美多巴联合盐酸普拉克索治疗。两个月为一个疗程，观察两组患者治疗效果及不良反应发生率。结果观察组患者总有效率为93．15％，对照组为83．56％；观察组不良反应发生率为13．70％，对照组为21．92％，差异均有统计学意义（均P＜0．05）。结论美多巴联合盐酸普拉克索治疗PD患者能够显著改善患者运动功能，降低并发症发生率。%Objective To explore the effect of Madopar combined with pramipexole hydrochloride as a medicine in treating Parkinson's disease(PD) and its effect on the kinematic function .Method 146 patients with Parkinson's disease were randomly divided into a control group and an experimental group , each consisting of 73 patients.The control group were treated with Madopar while the experimental group with Madopar combined with pramipexole hydrochloride .The course of treatment was two-month long .The therapeutic effect and the adverse reaction were observed .Findings The total effective rate as observed in the experimental group was 93.15%, higher than that of the control group , which was 83.56%.The adverse reaction rate of the experimental group was 13 .70%, lower than that of the control group , which was 21 .92%.The difference was statistically significant (P <0.05).Conclusion Madopar combined with pramipexole hydrochloride can serve as an effective therapy for PD , reduce the complications , and enhance the kinematic function of the patients .
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