Objective:To investigate the significances of quantitative electroencephalogram (QEEG) in evaluation of the prognosis of patients with widespread cerebral infarction in the medial cerebral artery (MCA) blood-supply area.Method:The clinical data on patients with widespread cerebral infarction in the MCA blood-supply area admitted into the department of neurology of our hospital between Feb .2010 and Jun.2013 was analyzed.The patients were short-term (in one month after the development of the disease ) or long-term (in three months after the development of the disease ) followed up.Patients with short-term fol-lowed up were divided into death group and survival group based on the prognosis of the patients ;while pa-tients with long-term followed up were divided into unfavorable prognosis group and favorable prognosis group based on the prognosis of the patients ( by CPCs classification method ) .The general information , clinical in-formation ( including blood pressure and serum homocysteic acid level ) , GCS scores ( Glasgow coma scores), and routine EEG and QEEG parameters and so on were compared between the groups , and ROC curve analysis was conducted on the predictive values of age , GCS score and QEEG parameter for the pa-tients.Result:As for short-term prognosis, the GCS score (t=2.348, P=0.019) and SEF95%(t=3.446, P<0.01) of the patients of the survival group were both higher than those of the death group , while theδab-solute energy (t=2.814, P<0.01) and θ absolute energy (t=2.104, P=0.018) of the patients of the sur-vival group were both lower than those of the death group , and all the differences were statistically signifi-cant.As for long-term prognosis, the age (t=2.951, P<0.01) and δabsolute energy (t=2.434, P<0.01) of the patients of the favorable prognosis group were significantly lower than those of the unfavorable prognosis group, and GCS score (t=2.963, P<0.01), SEF95%(t=2.725, P<0.01) and aEEG upper bound (t=2. 310, P<0.01) of the patients of the favorable prognosis group were significantly higher than those of the un-favorable prognosis group .The combined predictive value of age , GCS score and QEEG data had an area un-der curve of 0.932, sensitivity of 91.80%and specificity of 91.02%, and was significantly better than the predictive value of single age , GCS score or QEEG data .Conclusion:QEEG parameters ( such as SEF95%, aEEG upper bound and δabsolute energy ) combined with the age and GCS score of patients with cerebral in-fraction have important predictive values for patients with widespread cerebral infarction in the MCA blood -supply area .%目的：探讨（定量化脑电图） QEEG在大面积（大脑中动脉） MCA供血区脑梗塞患者预后评估中的意义。方法：分析2010年2月至2013年6月在我院神级内科病房接受住院治疗的大面积MCA供血区脑梗塞患者的临床资料。根据随访时间分为近期随访（发病后1月）和远期随访（发病后3月）。近期随访根据患者的预后分为死亡组和生存组；远期随访根据预后（ CPCs 分级方法）分为预后不良组和预后良好组。分别比较组间患者的一般信息、临床信息（包括患者血压、血清同型半胱氨酸水平等）、GCS评分（格拉斯哥昏迷评分）、常规脑电图检测及QEEG相关参数等，并对患者的年龄、GCS评分及QEEG参数对于患者的预后价值分别行ROC曲线分析。结果：对于近期预后，生存组患者的GCS评分（ t＝2．348，P＝0．019）和SEF95％（ t＝3．446，P＜0．01）均高于死亡组，而δ绝对频带能量（ t＝2．814，P＜0．01）、θ绝对频带能量（ t＝2．104，P＝0．018）均低于死亡组，差异均有统计学意义；对于远期预后，预后良好组患者的年龄（t＝2．951，P＜0．01）、δ绝对频带能量（t＝2．434，P＜0．01）显著低于预后不良组，而良好组患者的GCS评分（t＝2．963，P＜0．01）、SEF95％（t＝2．725，P＜0．01）和aEEG上界（t＝2．310，P＜0．01）显著高于不良组；患者年龄、GCS评分及QEEG数据三者联合预测价值的曲线下面积为0．932，敏感性为91．80％，特异性为91．02％，明显优于三者单独对于预后的预测价值。结论：QEEG 参数（如SEF95％、aEEG上界及δ绝对频带能量等）结合脑梗患者的年龄和GCS 评分对于大面积MCA脑梗患者预后有着重要的预测价值。
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