Discovering the cellular-localized functional modules and modular interactions in response to liver cancer

朱晶; Guo Zheng; Yang Da; Zhang Min; Wang Jing; Wang Chenguang

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Discovering the cellular-localized functional modules and modular interactions in response to liver cancer

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In this paper,we firstly identify the functional modules enriched with differentially expressed genes(DEGs) and characterized by biological processes in specific cellular locations,based on gene ontology(GO) and microarray data.Then,we further define and filter disease relevant signature modules accord-ing to the ranking of the disease discriminating abilities of the pre-seleeted functional modules.At last,we analyze the potential way by which they cooperate towards human disease.Application of the proposedmethod to the analysis of a liver cancer dataset shows that,using the same false discovery rate (FDR)threshold,we can find more biologically meaningful and detailed processes by using the cellular localiza-tion information.Some biological evidences support the relevancy of our biological modules to the diseasemechanism.

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《高技术通讯：英文版》 |2008年第4期|437-442|共6页
作者
朱晶; Guo Zheng; Yang Da; Zhang Min; Wang Jing; Wang Chenguang;
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作者单位

School of Life Science and Bioinformatics Centre;

University of Electronic Science and Technology of China;

Chengdu 610054;

P. R. China;

Department of Bioinformatics;

Bio-pharmaceutical Key Laboratory of Heilongjiang Province-Incubator of State Key Laboratory;

Harbin Medical University;

Harbin 150086;

P. R. China;

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原文格式 PDF
正文语种 chi
中图分类肝肿瘤;
关键词
肝癌; 基因表达; 癌细胞; DEGs;

机译：基因芯片;基因本体;功能模块;细胞定位;肝癌;

Discovering the cellular-localized functional modules and modular interactions in response to liver cancer

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