Objective To study the effect of the application of standardized management in patients with essential hypertension and their economic burden of disease.Methods In total 128 patients with essential hypertension who received treatment in our hospital from January to December 2014 were included in our study. Based on the principle of randomized controlled clinical trials, we divided them into control group and observation group randomly with 64 cases in each group. Patients in control group received routine management while patients in observation group received not only routine management but also standardized management. After 3-month intervention, the life quality of patients in both groups was tested with international universal life quality scale (SF-36) and the influence of patients' economic burden of disease in both groups were observed. Data of two groups were compared and analyzed with statistic methods.Results After the implementation of standardized management, patients' scores of all life quality dimensions in observation group were improved obviously among which scores of five dimensions including physiological function, physical disease, energy, social function and mental health were improved significantly with statistical significance (P<0.05) compared with scores before intervention; Compared with both the status before intervention and the results of control group, patients in observation group after intervention were in better condition in the aspects of physiological role, recovery of emotional function and general health status and there was statistically significant difference (P<0.05); After the implementation of standardized management, the total cost per year of outpatient expenditure, hospitalization, drugs of outpatient prescriptions and self-buying drugs was significantly lower than that of control group with statistical significance (P<0.05). Conclusion The application of standardized management in patients with essential hypertension can promote patients' recovery of physical, psychological and social functions, improve patients' life quality and reduce their economic burden.%目的探讨规范化管理对原发性高血压患者的应用效果及疾病经济负担的影响。方法对本院2014年1月-2014年12月收治的原发性高血压患者128例进行研究，按照临床试验随机对照的原则将患者随机分为两组，每组各64例，其中对照组采取常规的管理模式进行干预，观察组在对照组基础上采取规范化管理进行干预，3个月后对两组患者采用国际普适生活质量量表（SF-36）对患者的生活质量进行评定以及对比观察疾病经济负担的影响，并对两组数据进行统计分析和比较。结果实施规范化管理干预后，观察组患者生活质量各维度得分均明显提高，其中生理机能、躯体疾病、精力、社会功能、精神健康等5个维度得分与干预前相比具有显著性差异，P<0.05；且观察组患者在生理职能、情感功能的恢复及一般健康状况等方面相对处于较好状态，与干预前和对照组相比，差异均具有统计学意义，P<0.05；且实施规范化管理干预后，观察组高血压患者的门诊总费用、年住院总费用、年门诊开药总费用、年自购药总费用均显著低于对照组，差异有统计学意义，P<0.05。结论对原发性高血压患者及时实施规范化管理干预，可不同程度地促进患者生理、心理和社会功能的康复，更大程度上提高患者生活质量，大大减轻了经济负担。
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