Toxic substances leakage may lead to serious environmental pollution or personal injuries ,it is of great signifi-cance for environmental protection ,emergency rescue and risk assessment to analyze diffusion rule of toxic substances and main influencing factors .In this paper Hydrogen chloride ,ammonia ,and liquid bromine have been chosen as the simulation objects ,sensitivity analysis calculations of the main parameters affecting the diffusion distance have been carried out and the degree of influence on the diffusion distance by changing parameter values have been analyzed .The results show that the in-fluences of parameters are related to the physical properties of the substances and the boiling point of the substances is one of the main factors affecting the diffusion distance .%毒性物质泄漏可能引发严重的环境污染或人员伤亡，分析毒性物质扩散规律及主要影响因素，对环境保护、应急救援和风险评估具有重大意义。选择了氯化氢、氨气、液溴3种有毒物质作为模拟对象，对影响毒性物质扩散的主要参数进行敏感性分析计算，分析了参数值的变化对扩散距离的影响程度。结果表明，参数的影响与泄漏物质自身性质有关，物质的沸点是影响扩散的主要因素之一。
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