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首页> 中文期刊> 《贫困所致传染病（英文）》 >Usefulness of interferon-γrelease assay for the diagnosis of sputum smear-negative pulmonary and extra-pulmonary TB in Zhejiang Province,China

Usefulness of interferon-γrelease assay for the diagnosis of sputum smear-negative pulmonary and extra-pulmonary TB in Zhejiang Province,China

         
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摘要

Background:Quick diagnosis of smear-negative pulmonary tuberculosis(TB)and extra-pulmonary TB are urgently needed in clinical diagnosis.Our research aims to investigate the usefulness of the interferon-γrelease assay(IGRA)for the diagnosis of smear-negative pulmonary and extra-pulmonary TB.Methods:We performed TB antibody and TB-IGRA tests on 389 pulmonary TB patients(including 120 smear-positive pulmonary TB patients and 269 smear-negative pulmonary TB patients),113 extra-pulmonary TB patients,81 patients with other pulmonary diseases and 100 healthy controls.Blood samples for the TB-Ab test and the TB-IGRA were collected,processed,and interpreted according to the manufacturer’s protocol.Results:The detection ratio of smear-positive pulmonary TB patients and smear-negative pulmonary TB patients were 90.8%(109 of 120)and 89.6%(241 of 269),respectively.There was no statistically significant difference of its performance between these two sample sets(P>0.05).The detection ratio of positive TB patients and extra-pulmonary TB patients were 90.0%(350 of 389)and 87.6%(99 of 113),respectively,which was not significantly different(P>0.05).Conclusions:In this work,the total detection ratio using TB-IGRA was 89.4%,therefore TB-IGRA has diagnostic values in smear-negative pulmonary TB and extra-pulmonary TB diagnosis.

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  • 来源
    《贫困所致传染病（英文）》 |2017年第001期|P.1074-1078|共5页
  • 作者

    Lei Ji; Yong-Liang Lou; Zhong-Xiu Wu; Jin-Qin Jiang; Xing-Li Fan; Li-Fang Wang; Xiao-Xiang Liu; Peng Du; Jie Yan; Ai-Hua Sun;

  • 作者单位

    Department of Basic Medicine Hangzhou Medical College Hangzhou 310053 Zhejiang People’s Republic of China;

    School of Laboratory Medical Science and Life Science Wenzhou Medical University Wenzhou 325035 Zhejiang People’s Republic of China;

    Zhejiang Blood Center Hangzhou 310006 Zhejiang People’s Republic of China;

    Department of Basic Medicine Hangzhou Medical College Hangzhou 310053 Zhejiang People’s Republic of China;

    Department of Basic Medicine Hangzhou Medical College Hangzhou 310053 Zhejiang People’s Republic of China;

    Department of Basic Medicine Hangzhou Medical College Hangzhou 310053 Zhejiang People’s Republic of China;

    Department of Basic Medicine Hangzhou Medical College Hangzhou 310053 Zhejiang People’s Republic of China;

    Department of Basic Medicine Hangzhou Medical College Hangzhou 310053 Zhejiang People’s Republic of China;

    Division of Basic Medical Microbiology State Key Laboratory for Diagnosis and Treatment of Infectious Diseases First Affiliated Hospital of Zhejiang University Hangzhou 310003 Zhejiang People’s Republic of ChinaDepartment of Medical Microbiology and Parasitology College of Medicine Zhejiang University Hangzhou 310058 Zhejiang People’s Republic of China;

    Department of Basic Medicine Hangzhou Medical College Hangzhou 310053 Zhejiang People’s Republic of ChinaSchool of Laboratory Medical Science and Life Science Wenzhou Medical University Wenzhou 325035 Zhejiang People’s Republic of China;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 中国工业经济;
  • 关键词

    Interferon-gamma release assay; Smear-negative pulmonary TB; Extra-pulmonary TB;

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