在后基因组时代,比较基因组学已经成为诠释遗传信息生物学意义的重要方法.运用生物信息学的手段,比较分析不同细菌的基因组,我们逐步揭示了细菌染色体物理结构的保守性和基因内容多样性的产生机制.进化生物学家们正试图从基因组数据库中挖掘能够代表物种进化关系的具有普遍适用性的分子线索,重建生命进化树.%Placing genomes into an evolutionary framework has proved to be usefol for deciphering the genome sequences of organisms.Comparative genomies,as a routine toolkit.has substantially incteased the understanding of the processes by which bacterial genomes evolve and led to a re-evaluation of the history of life.In this review,we present some of the most important recent advances and promising leads in the field of bacterial evolutionary genomics.
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