Transit time ultrasound perivascular flow probe technology is superior to MR imaging on hepatic blood flow measurement in a porcine model

Mohamed Bekheit; Chloe Audebert; Petru Bucur; Hans Adriaensen; Emilie Bled; Mylène Wartenberg; Irene Vignon-Clementel; Eric Vibert

首页> 中文期刊> 《国际肝胆胰疾病杂志（英文版）》 >Transit time ultrasound perivascular flow probe technology is superior to MR imaging on hepatic blood flow measurement in a porcine model

Transit time ultrasound perivascular flow probe technology is superior to MR imaging on hepatic blood flow measurement in a porcine model

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Background: The hepatic hemodynamics is an essential parameter in surgical planning as well as in var-ious disease processes. The transit time ultrasound (TTUS) perivascular flow probe technology is widely used in clinical practice to evaluate the hepatic inflow, yet invasive. The phase-contrast-MRI (PC-MRI) is not invasive and potentially applicable in assessing the hepatic blood flow. In the present study, we com-pared the hepatic inflow rates using the PC-MRI and the TTUS probe, and evaluated their predictive value of post-hepatectomy adverse events. Methods: Eighteen large white pigs were anaesthetized for PC-MRI and approximately 75％ hepatic resec-tion was performed under a unified protocol. The blood flow was measured in the hepatic artery (Qha), the portal vein (Qpv), and the aorta above the celiac trunk (Qca) using PC-MRI, and was compared to the TTUS probe. The Bland-Altman method was conducted and a partial least squares regression (PLS) model was implemented. Results: The mean Qpv measured in PC-MRI was 0.55 ± 0.12 L/min, and in the TTUS probe was 0.74 ± 0.17 L/min. Qca was 1.40 ± 0.47 L/min in the PC-MRI and 2.00 ± 0.60 L/min in the TTUS probe. Qha was 0.17 ± 0.10 L/min in the PC-MRI, and 0.13 ± 0.06 L/min in the TTUS probe. The Bland-Altman method revealed that the estimated bias of Qca in the PC-MRI was 32％ (95％ CI: ?49％ to 15％); Qha 17％ (95％ CI:?15％ to 51％); and Qpv 40％ (95％ CI: ?62％ to 18％). The TTUS probe had a higher weight in predicting adverse outcomes after 75％ resection compared to the PC-MRI (β= 0.35 and 0.43 vs β = 0.22 and 0.07, for tissue changes and premature death, respectively). Conclusions: There is a tendency of the PC-MRI to underestimate the flow measured by the TTUS probes. The TTUS probe measures are more predictive of relevant post-hepatectomy outcomes.

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《国际肝胆胰疾病杂志（英文版）》 |2018年第6期|538-545|共8页
作者
Mohamed Bekheit; Chloe Audebert; Petru Bucur; Hans Adriaensen; Emilie Bled; Mylène Wartenberg; Irene Vignon-Clementel; Eric Vibert;
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作者单位

Inserm Unité 1193;

112 Boulevard Paul Valliant Cuturier;

Villejuif;

France;

Institute of medical sciences;

University of Aberdeen;

Aberdeen;

UK;

Centre de recherche Inria de Paris;

Paris;

France;

Sorbonne Universités;

UPMC University of Paris 6;

Laboratoire Jacques-Louis;

Lions;

Paris;

France;

Inserm Unité 1193;

112 Boulevard Paul Valliant Cuturier;

Villejuif;

France;

CHRU;

h?pitaux de Tours;

Chirurgie Hépato-biliaire et Pancréatique;

Transplantation Hépatique;

Tours;

France;

Plateforme Chirurgie et Imagerie pour le Recherche et l'Enseignement (CIRE);

Imagerie;

UMR-PRC;

37380 Nouzilly;

Centre INRA Val de Loire;

France;

Plateforme Chirurgie et Imagerie pour le Recherche et l'Enseignement (CIRE);

Imagerie;

UMR-PRC;

37380 Nouzilly;

Centre INRA Val de Loire;

France;

Centre de recherche Inria de Paris;

Paris;

France;

Centre de recherche Inria de Paris;

Paris;

France;

Sorbonne Universités;

UPMC University of Paris 6;

Laboratoire Jacques-Louis;

Lions;

Paris;

France;

Inserm Unité 1193;

112 Boulevard Paul Valliant Cuturier;

Villejuif;

France;

AP-HP;

H?pital Paul Brousse;

Centre Hépato-Biliaire;

Villejuif;

France;

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正文语种 eng
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Transit time ultrasound perivascular flow probe technology is superior to MR imaging on hepatic blood flow measurement in a porcine model

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