Objective To study the relationship between the concentration of oxidized low density lipoprotein(Ox-LDL)and ca-rotid intima-media thickness(IMT)in acute cerebral infarction(ACI group).Methods 44 ACI patients(ACI group)and 30 healthy individuals(control group)were enrolled in the study,whose serum concentrations of Ox-LDL were determined by using enzyme-linked immunosorbent assay(ELISA),and carotid IMT of ACI patients were measured by using ultrasound,then the relationship between Ox-LDL and carotid IMT of ACI patients was analysed.Results The serum concentration of Ox-LDL in ACI group was significantly higher than that in control group(P <0.01).In ACI group,the serum concentration of Ox-LDL was positively correla-ted with carotid IMT(r =0.493,P <0.05 ).In ACI group,the serum Ox-LDL concentrations of patients whose IMT≥1.0 were higher than patients whose IMT<1.0 mm(P <0.05).Ox-LDL concentrations of ACI patients were positively correlated with the carotid IMT(r =0.493,P <0.05 ).Conclusion The serum concentration of Ox-LDL increased significantly in ACI patients,and was closely related to carotid atherosclerosis.%目的：研究急性脑梗死（ACI）患者氧化低密度脂蛋白（Ox-LDL）与颈动脉内膜中层厚度（IMT）之间的关系。方法采用酶联免疫吸附测定（ELISA）检测44例 ACI 患者（ACI 组）和30例健康者（对照组）血清 Ox-LDL 水平，并对 ACI 患者进行颈动脉超声检查，检测颈动脉 IMT，分析 ACI 患者 Ox-LDL 水平与颈动脉 IMT 的关系。结果ACI 患者 Ox-LDL 水平明显高于健康者，差异有统计学意义（P ＜0．01）；颈动脉 IMT≥1．0 mm 的 ACI 患者 Ox-LDL 水平高于颈动脉 IMT＜1．0 mm 者（P ＜0．05）；ACI 患者 Ox-LDL 水平与颈动脉 IMT 呈正相关（r＝0．493，P ＜0．05）。结论ACI 患者的血清 Ox-LDL 水平升高，与颈动脉粥样硬化密切相关。
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