Lipid accumulation and protein modifications of Bruch’s membrane in age-related macular degeneration

Li-Hui Meng; You-Xin Chen

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Lipid accumulation and protein modifications of Bruch’s membrane in age-related macular degeneration

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Age-related macular degeneration(AMD)is a progressive retinal disease,which is the leading cause of blindness in western countries.There is an urgency to establish new therapeutic strategies that could prevent or delay the progression of AMD more efficiently.Until now,the pathogenesis of AMD has remained unclear,limiting the development of the novel therapy.Bruch’s membrane(BM)goes through remarkable changes in AMD,playing a significant role during the disease course.The main aim of this review is to present the crucial processes that occur at the level of BM,with special consideration of the lipid accumulation and protein modifications.Besides,some therapies targeted at these molecules and the construction of BM in tissue engineering of retinal pigment epithelium(RPE)cells transplantation were listed.Hopefully,this review may provide a reference for researchers engaged in pathogenesis or management on AMD.

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《国际眼科杂志：英文版》 |2021年第5期|P.766-773|共8页
作者
Li-Hui Meng; You-Xin Chen;
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作者单位

Department of Ophthalmology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 ChinaKey Laboratory of Ocular Fundus Diseases Chinese Academy of Medical Sciences&Peking Union Medical College Beijing 100730 China;

Department of Ophthalmology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 ChinaKey Laboratory of Ocular Fundus Diseases Chinese Academy of Medical Sciences&Peking Union Medical College Beijing 100730 China;

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原文格式 PDF
正文语种 chi
中图分类计算技术、计算机技术;
关键词
Bruch’s membrane; lipid accumulation; protein modifications; therapy;

机译：Bruch的膜;脂质积累;蛋白质修饰;治疗;

Lipid accumulation and protein modifications of Bruch’s membrane in age-related macular degeneration

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