DNA repair and synthetic lethality

Gong-she Guo; Feng-mei Zhang; Rui-jie Gao; Robert Delsite; Zhi-hui Feng; Simon N.Powell

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DNA repair and synthetic lethality

机译：DNA修复和合成杀伤力

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Tumors often have DNA repair defects, suggesting additional inhibition of other DNA repair pathways in tumors may lead to synthetic lethality. Accumulating data demonstrate that DNA repair-defective tumors, in particular homologous recombination (HR), are highly sensitive to DNA-damaging agents. Thus, HR-defective tumors exhibit potential vulnerability to the synthetic lethality approach, which may lead to new therapeutic strategies. It is well known that poly (adenosine diphosphate (ADP)-ribose) polymerase (PARP) inhibitors show the synthetically lethal effect in tumors defective in BRCA1 or BRCA2 genes encoded proteins that are required for efficient HR. In this review, we summarize the strategies of targeting DNA repair pathways and other DNA metabolic functions to cause synthetic lethality in HR-defective tumor cells.

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《国际口腔科学杂志（英文版）》 |2011年第4期|176-179|共4页
作者
Gong-she Guo; Feng-mei Zhang; Rui-jie Gao; Robert Delsite; Zhi-hui Feng; Simon N.Powell;
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School of Public Health,Shandong University,Jinan 250012,China;

School of Public Health,Shandong University,Jinan 250012,China;

Second People's Hospital of Weifang,Weifang 261041,China;

Department of Radiation Oncology,Memorial Sloan Kettering Cancer Center,New York NY 10065,USA;

School of Public Health,Shandong University,Jinan 250012,China;

Department of Radiation Oncology,Washington University in St Louis,St Louis MO 63108,USA;

Department of Radiation Oncology,Memorial Sloan Kettering Cancer Center,New York NY 10065,USA;

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DNA repair and synthetic lethality

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